Research Core Services
The Lerner Research Institute's Core Services seek to facilitate and advance research throughout Cleveland Clinic by providing technologies that support basic, translational, and clinical research.
The Genomics Core is a recent addition to the CCF / LRI Core services community and will provide research groups access to state-of-the-art genomics capabilities (sequencing, genotyping and gene expression arrays).
The Core now performs next generation sequencing using the Illumina HiSeq2500 and the MiSeq. With this technology, we sequence DNA, RNA, micro-RNAs and perform ChIP-Seq and whole exome sequencing. To support traditional capillary sequencing and microsatellite genotyping projects, the Genomics Core is equipped with an ABI 3730xl DNA analyzer. For the array-based genotyping and expression array projects, the Core has now installed an Illumina iScan system, which is a cutting-edge array scanner that supports rapid, sensitive, and accurate imaging of Illumina BeadChips for genetic analysis results. The iScan supports Illumina's broad range of innovative genetic analysis assays for genotyping, CNV analysis, DNA methylation, and gene expression profiling. For custom gene expression projects the Genomics Core has a platform that uses sets of human and mouse custom arrays whose probe content is aimed at gene expression studies in the areas of cancer, immunology and other complex diseases. For more detailed description of the services we provide or if you have any questions please contact the Genomics Core