Research Core Services
The Lerner Research Institute's Core Services seek to facilitate and advance research throughout Cleveland Clinic by providing technologies that support basic, translational, and clinical research.
The MicroCT Core makes available instrumentation and staff assistance for non-invasive anatomical imaging of rodents. In vivo imaging of animal models enables investigators to monitor disease progression and the pre-clinical efficacy of novel therapeutic agents over time, thereby reducing the variability in studies designed with multiple subjects. It also reduces the number of animals required because it eliminates the need to sacrifice animals at multiple time points. The Locus RS microCT generates isotropic 3D representation of the specimen at resolutions ranging from 20-93um, at voltages ranging from 35kV to 80kV. This allows image acquisition of both hard tissues and some soft tissues. The system is also setup to allow for live-animal contrast injections and also for respiratory gating. In addition to expert support and training on instruments, Core staff provides consultation in developing imaging protocols and assistance with image reconstruction and analysis. All Core facilities comply with IACUC and Radiation Safety regulations and are routinely inspected.