Postdoctoral 4

Date Contact Description
11/30/2018 John Pellecchia
pellecj@ccf.org

Postdoctoral research fellow positions will be available in the laboratory of Dr. Li (Lily) Wang at the Cleveland Clinic Taussig Cancer Institute’s Department of Translational Hematology & Oncology Research (THOR), https://my.clevelandclinic.org/departments/cancer/depts/thor), located within the Lerner Research Institute (LRI), Cleveland Clinic Foundation, Cleveland, OH. The Wang laboratory is relocating from the Medical College of Wisconsin, Milwaukee, WI to Cleveland Clinic, and will be engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI including the Department of Inflammation and Immunology (https://www.lerner.ccf.org/immuno/), and the Case Comprehensive Cancer Center, affiliated with Case Western Reserve University.

Immune-checkpoint blockade (ICB) therapies have revolutionized the field of Cancer Immunotherapy. However, the low response rate in a majority of patients indicates the urgent need to identify and target additional checkpoint regulators. The Wang lab was the first group to demonstrate that a new immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) is a promising target for cancer immunotherapy (1 – 5). Our studies show that VISTA regulates the effector functions of cytotoxic T cells, myeloid-derived suppressor cells (MDSC), and myeloid inflammatory DCs. Current projects are focusing on elucidating the molecular signaling mechanisms of VISTA and design innovative approaches to target this checkpoint protein for cancer therapy.

We therefore seek talented and committed candidates with a recent Ph.D. in Biochemistry, Cell Biology, Immunology, or other relevant branches of biological sciences to join our team and make significant contributions to the field of Cancer Immunotherapy. Interested candidates should submit CV, a statement of research interests in a cover letter, and three references to John Pellecchia MS, Department Administrator, at pellecj@ccf.org

References:

 

1.Wang L, RubinsteinR, Lines LJ, Wasiuk A, AhonenC, GuoYX, LuLF, Gondek D, WangY, Fava RA, Fiser A, Almo S and Noelle RJ. (2011) ­­­VISTA, a novel Ig-superfamily ligand that negatively regulates T cell responses, J Exp Med. 208(3):577-92. PMC3058578

2. Le Mercier I, Chen W, Lines JL, Day M, Li J, Sergent P, Noelle RJ, Wang L (2014) VISTA regulates the development of protective anti-tumor immunity. Cancer Research, 74:1933-1944. PMC4116689

3. Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ. (2014) Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. PNAS.  (41):14846-51 PMC4205642

4. Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller H, Guleria I, Barth RJ, Huang YH, Wang L (2015) Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. PNAS. 112(21):6682-7, PMC4450438

5. Xu W, Tạ MH, Malarkannan S, Wang L(2018) Review: The structure, expression, and function of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation. Cellular & Molecular Immunology. 2018 May 15(5):438-446PMC6068175

11/04/2018 Mohamed Abazeed
abazeem@ccf.org

The Abazeed laboratory at the Cleveland Clinic Foundation has an immediate opening for a highly motivated individual with expertise in genomic and machine learning informatics. These positions are supported by multi-sourced grants.

Fellows will lead the design and implementation of data analysis projects addressing fundamental biological questions about the causes and consequences of inter- and intra-tumoral genetic variation in cancer. These projects involve integrated analysis of high-volume genomic, epigenomic, and gene expression data (next-generation sequencing – WES/WGS, RNA-seq, Bisulfite-seq, etc.). Successful candidates will work independently and take a leading role in data analysis, interpretation, and visualization, and drafting of manuscripts for publication.

Recent PhDs in computer science, bioinformatics, computational biology, and related fields will be considered. A strong background in statistics, and programming experience in a UNIX/Linux environment using programming languages such as Perl are required. Experience in high-throughput analysis of next-generation sequencing data and familiarity with widely-used genomic databases and software are advantageous.

The candidate must have excellent verbal and written communication skills and be capable of working within a team of biologists and programmers. A background in biology is not required, but the ideal candidate will have some familiarity with genetics and genomics. This opportunity could present an outstanding training experience for someone with a solid computer science background who wishes to break into bioinformatics.

To apply, submit your CV, statement of research interests, and names and contact information of three references to: Mohamed E. Abazeed, MD, PhD, Department of Translational Hematology Oncology Research, Cleveland Clinic Foundation, 2111 East 96th St/NE6, 44195; E-mail: abazeem@ccf.org.

11/04/2018 Mohamed Abazeed
abazeem@ccf.org

We are seeking a Postdoctoral Research Fellow to join our research team in the Department of Translational Hematology and Oncology Research at the Cleveland Clinic Lerner Research Institute.  Our NIH funded research program is focused on studying mechanisms that underliethe susceptibility of tumors to radiotherapy, clinicalresearch on newtreatments andtranslationalresearchto combinethese approachestoimprove the outcomes of cancer patients 

Our multi-faceted research program includes experts in computational, murine and cellular biology. We are seeking to augment our depth by hiring a dynamic scientist who enjoys working in a trans-disciplinary team environment with multi-faceted mentorship and career development opportunities.

Recent Ph.D. graduates or postdoctoral fellows with a background in molecular, cell and murine biology are encouraged to apply. The candidate should have a publication record demonstrating hands-on experimental expertise and experience in several labs skills including but not limited to: primary human cell culture, PCR, Western blotting, CRISPR, high-content cellular profiling and several murine tasks (breeding, genotyping, xenografting, administration of drugs [I.P. or by gavage] and radiation, et cetera).

Proficiency in spoken and written English are also required.

To apply, submit your CV, statement of research interests, and names and contact information of three references to: Mohamed E. Abazeed, MD, PhD, Department of Translational Hematology Oncology Research, Cleveland Clinic Foundation, 2111 East 96th St/NE6, 44195; E-mail: abazeem@ccf.org.

06/13/2018 Omar Mian, MD, PhD
miano@ccf.org

Postdoctoral fellow positions are available in the laboratory of Omar Mian, M.D., Ph.D., in the Department of Translational Hematology and Oncology Research (THOR) at the Cleveland Clinic’s Lerner Research Institute in Cleveland, OH.  

Currently funded projects focus on studying epigenetic, metabolic, and endocrine determinants of response to DNA damage in a variety of cancers. The work involves characterization of innovative preclinical models using genome editing and molecular analysis methods. Clinical samples are readily available for validation studies. The position offers excellent opportunities for publication and career development in a stimulating academic environment.

Highly motivated individuals with a strong background and interest in translational cancer research, and with the ability to multitask in a fast-paced lab, are encouraged to apply. Applicants must be recent Ph.D. or M.D./Ph.D. graduates in cell biology, molecular biology, cancer biology, molecular genetics, developmental biology or related fields. Prior experience in culture of human primary and cancer cell lines, molecular biology, as well as a track record of peer-reviewed publications is required. Individuals with additional experience in genome editing, mouse work or bioinformatics, are strongly encouraged to apply.

Interested applicants should send a CV, a cover letter/statement that describes career goals, and 3 references to Dr. Omar Mian (miano@ccf.org).



Technical & Adminstrative

Applications for technical research positions and administrative positions at the Lerner Research Institute can be submitted on the Cleveland Clinic jobs web site.