Welcome to the Theory Division at Cleveland Clinic, started in August 2016 !

Cancer is a complex disease that is an aberration of our own tissues, but it still obeys fundamental biological rules. Our greatest challenge in the clinic is the emergence of resistance to our therapies, a process which is governed by Darwinian evolution. Using a suite of mathematical and experimental models, my laboratory seeks to deconvolute the complexity of the evolutionary process into fundamental principles. We aim to use this knowledge to then curtail the evolutionary process to increase the efficacy of targeted therapies and radiation. This same knowledge can be further harnessed to understand the differences in disease progression and therapy response on a personalized basis, so that the right treatment can be given to the right patient at the right time.

Please consider making a donation to my Velosano charity ride this summer in support of cancer research. Click on the Velosano icon above to be taken to my donation page. One hundred percent of donations goes directly to cancer research, and in fact, our lab received $100,000 this past year from this charity to create an automated culture device to speed the study of leukemia evolution!