Our lab is committed to creating and maintaining an environment in which all are welcome and respected - one that is inclusive of race, gender, faith, sexual orientation, ability, and socioeconomic status. We acknowledge that many identities are underrepresented in STEM and in academia, and that systemic racism and other discriminations create obstacles for students and postdocs. We strongly condemn behaviors and institutions that perpetuate these inequities, and we as a lab must act to dismantle the structural and systemic barriers to higher education.

The mission of our lab is to create a space for students and postdocs to develop the skills necessary to be able to effectively question, research, and communicate scientific topics. We understand that differences will exist in the level of training, knowledge, personal circumstances, and life and career goals of lab members. As such, our goal is to provide an equitable academic opportunity while taking these conditions into account.

Jacob Scott, MD, DPhil

Principal Investigator
Staff, Departments of Translational Hematology and Oncology Research and Radiation Oncology
Adjunct Assistant Professor, Department of Physics, Case Western Reserve University

I am a veteran of the US Navy submarine force turned academic physician-scientist. Our lab pursues research decomposing the complexity of cancer through mathematical modeling and the biological and clinical validation of these models. My educational background in physics, medicine, mathematics and engineering gives me a unique perspective on cancer and systems biology and I am able to communicate and collaborate with professionals across many disciplines. I have worked extensively on mathematical modeling of cancer evolution and treatment using a variety of models including evolutionary game theory, cellular automata, differential equations and Markov chains. My DPhil thesis focused on the role of heterogeneity, both genetic and microenvironmental, on cancer evolution and radiation response, and my laboratory’s focus is cancer evolution and therapy resistance. Since starting Theory Division, we have begun to diversify, and the lab now has a significant experimental component, conducting experimental evolution in cancer cell lines as well as bacteria. The combination of mathematics, experimental evolution and a clinical focus makes our laboratory stand out as one of the most interdisciplinary in the field of translational cancer evolution and evolutionary medicine. I am eager to use my distinct perspective to help advance this field to help cancer patients.
Email: scottj10@ccf.org
Twitter: @CancerConnector
Google Scholar

Lab members (listed alphabetically)

Kyle Card, PhD

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Jay Crump

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Mina Dinh

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Arda Durmaz

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Patrick Ellsworth

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Bezhou Feng

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Vishhvaan Gopalakrishnan, MD

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Dena Guo

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Masahiro Hitomi, MD, PhD

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Emily Ho

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Linh Huynh

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Eshan King

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Nikhil Krishnan, MD

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Kristi Lin-Rahardja

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Jeff Maltas, PhD

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Luka Opašić, MD, PhD

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Steph Owen, PhD

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Julia Pelesko

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Jessica Scarborough

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Eashwar Somasundaram

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Dagim Shiferaw Tadele, PhD

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Raoul Wadhwa

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Davis Weaver

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Kailin Yang, MD, PhD

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Lab alumni (listed by date of departure)

Drew F. K. Williamson, MD

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Inom Mirzaev, PhD

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Elena Svenson, PhD

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Erin McClure

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Nara Yoon, PhD

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Andrew Dhawan, MD, DPhil

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Zahraa Al-Turaihi, MD

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Emily Dolson, PhD

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Artem Kaznatchev, PhD

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Geoff Sedor, MD

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Nathan Farrokhian

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