Location: Cleveland Clinic Main Campus
We work with nanotechnology (very tiny structures, much smaller than a human hair), which we call nanoengineered materials (NEM). Tumors can be destroyed noninvasively (without surgery) by shining low-intensity lasers on NEMs within the tumors. Our unique NEMs are made to give patients safe, non-invasive, and localized treatment (in a certain part of the body, rather than the whole body).
In our lab, we are designing sunscreens that are long-lasting, non-irritating, and effective in protecting skin from harmful sunlight. For breast cancer, we are researching how to combine imaging and treatment so that both can be done at the same visit.
Our lab is developing next-generation nanotechnologies for safe and effective treatment and prevention of diseases.
A. Antimicrobial Coatings to Prevent Disease Transmission
We have developed PhotoProtect, a transparent, self-cleaning, continuously active antimicrobial coating that kills and degrades microorganisms. PhotoProtect utilizes the visible light absorption by the contaminants, including microbes, to activate free radical production by TiO2-containing nanocomposites for the degradation of contaminants. Low-level visible light absorption by microbes is sufficient to activate the coating for their inactivation, and the inactivation rate is enhanced by use of an auxiliary light harvester. PhotoProtect can be easily applied to all surfaces and a single application is effective for at least one year.
B. Novel Sunscreens to Prevent Skin Cancers
We are developing PhotoSorb, which is an effective, safe, multifunctional active for sunscreen that replaces the multiple actives present in current sunscreens. Preliminary studies have demonstrated that PhotoSorb is effective at very low concentration and can delay or prevent skin cancers.
C. Non-Invasive and Safe Cancer Treatment
We are engineering photonic nanoparticles with high photothermal conversion efficiency for non-invasive and localized tumor destruction. Early studies suggest safe and rapid cancer treatment.
D. Enzyme-Mimicking Nanoparticles for Healthy Aging
We are utilizing picoscale surface engineering approaches to design novel enzyme-mimicking nanoparticles. These nanoparticles can stimulate growth across kingdoms and extend lifespan in animals. Novel enzyme mimics are being developed to prevent aging-associated diseases.
View publications for Vijay Krishna, PhD
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Chen A, Grobmyer SR, Krishna VB. Photothermal Response of Polyhydroxy Fullerenes. ACS Omega, 2020 Jun 4;5(24):14444-14450. doi: 10.1021/acsomega.0c01018. eCollection 2020 Jun 23.
*Indeglia, P., Georgieva, A, Krishna, V., Martyniuk, C., and Bonzongo, J-C., “Toxicity of functionalized fullerene and fullerene synthesis chemicals,” Chemosphere, 207, 1–9, 2018.
*Krishna, V., Bai, W., Han, Z., Yano, A., Thakur, A., Georgieva, A., Tolley, K., Navarro, J., Koopman, B., and Moudgil, B., “Contaminant-activated visible light photocatalysis,” Scientific Reports, 8, 1894, 2018. 11th in Top 100 Scientific Reports Chemistry Papers 2018
*Krishna, V., Zhao, J., Koopman, B., and Moudgil, B., “Purification procedure sensitizes Bacillus endospores to free radicals from UVA radiation and photocatalysis,” International Journal of Astrobiology, 1–7, 2017.
Nandakumar, V., Han, Z., Fritz, Z., Krishna, V., Koopman, B., and *Moudgil, B., “Visible light photocatalytic bacterial inactivation on titanium dioxide coatings,” KONA Powder and Particle Journal, 34, 234–240, 2017.
Krishna, V., Zhao, J., Pumprueg, S., Koopman, B., and *Moudgil, B., “Improving dispersion of bacterial endospores for enumeration,” KONA Powder and Particle Journal, 33, 304–309, 2016.
*Indeglia, P., Georgieva, A, Krishna V., and Bonzongo, J-C., “Physicochemical characterization of fullerenol and fullerenol synthesis by-products prepared in alkaline media,” Journal of Nanoparticle Research, 16:2599, 1–15, 2014.
*Indeglia, P., Krishna V., Georgieva, A, and Bonzongo, J-C., “Mechanical transformation of fullerene (C60) to aqueous nano-C60 (aqu-nC60) in the presence and absence of light,” Journal of Nanoparticle Research, 15 (11), 1–6, 2013.
*Georgieva, A., Pappu, V., *Krishna, V., Georgiev, P., Ghiviriga, I., Indeglia, P., Xu, X., Fan, H., Koopman, B., Pardalos, P., and *Moudgil, B., “Polyhydroxy fullerenes,” Journal of Nanoparticle Research, 15 (7), 1–18, 2013.
Grobmyer, S., and Krishna, V., “Minimally invasive cancer therapy using polyhydroxy fullerenes,” European Journal of Radiology, 81, S51–S53, 2012.
Bai, W., Krishna, V., Wang, J., Moudgil, B., and *Koopman, B., “Enhancement of nano titanium dioxide photocatalysis in transparent coatings by polyhydroxy fullerenes,” Applied Catalysis B: Environmental, 125, 128–135, 2012.
Gao, J., Wang, Y., Folta, K., Krishna, V., Bai, W., Indeglia, P., Georgieva, A., Nakamura, H., Koopman, B., and *Moudgil, B., “Polyhydroxy fullerenes (fullerols or fullerenols): Beneficial effects on growth and lifespan in diverse biological models,” PLoS One, 6 (5), 19976, 2011.
*Grobmyer, S., Morse, D., Fletcher, B., Gutwein, L., Sharma, P., Krishna, V., Frost, S., Moudgil, B., Brown, S., “The promise of nanotechnology for solving clinical problems in breast cancer,” Journal of Surgical Oncology, 103 (4), 317–325, 2011.
*Krishna, V., Singh, A., Sharma, P., Wang, Q., Zhang, Q., Nobutaka, I., Jiang, H., Koopman, B., Grobmyer, S., and Moudgil, B., “Polyhydroxy fullerenes for non-invasive cancer imaging and therapy,” Small, 6 (20), 2236–2241, 2010.
Singh, A., Krishna, V., Angerhofer, A., Do, B., MacDonald, G., and *Moudgil, B., “Copper coated silica nanoparticles for odor removal,” Langmuir, 26 (20), 15837–15844, 2010.
Sharma, P., Brown, S., Singh, A., Iwakuma, N., Pyrgiotakis, G., Krishna, V., Knapik, J., Barr, K., Moudgil, B., and *Grobmyer, S., “Near infrared absorbing and luminescent gold speckled silica nanoparticles for photothermal therapy,” Journal of Materials Chemistry, 20, 5182–5185, 2010.
*Krishna, V., Stevens, N., Koopman, B., and Moudgil, B., “Optical heating and transformation of functionalized fullerenes,” Nature Nanotechnology 5 (5), 330–334, 2010.
*Zhao, J., Krishna, V., Hua, B., Moudgil, B., and Koopman, B., “Effect of UVA irradiance on photocatalytic and UVA inactivation of B. cereus spores,” Journal of Photochemistry and Photobiology B, 94, 96–100, 2009.
*Zhao, J., Krishna, V., Moudgil, B., and Koopman, B., “Evaluation of endospore purification method applied to Bacillus cereus,” Separation and Purification Technology 61, 341–347, 2008.
Krishna, V., Yanes, D., Imaram, W., Angerhofer, A., Koopman, B., and *Moudgil, B., “Mechanism of enhanced photocatalysis with polyhydroxy fullerenes,” Applied Catalysis B Environmental 79, 376–387, 2008.
Krishna, V., Noguchi, N., Koopman, B. and *Moudgil, B., “Enhancement of titanium dioxide photocatalysis with water-soluble fullerenes,” Journal of Colloid and Interface Science, 304 (1), 166–171, 2006.
*Moudgil, B., Brown, S., and Krishna, V., “Nanotechnology’s challenges = Equipment manufacturers’ opportunities,” Powder and Bulk Engineering, 20 (5), 99–104, 2006.
Yeruva, S., Krishna, V., Moudgil, B. and El-Shall, H., “Nanomaterials: Synthesis, properties and applications,” Industrial Minerals and Rocks 7th Ed., J. Kogel, N. Trivedi, J. Barker and S. Krukowski (Eds.), Society for Mining, Metallurgy and Exploration, 1441-1453, 2006.
Powers, K., Brown, S., Krishna, V., Wasdo, S., Moudgil, B., and *Roberts, S., “Research Strategies for Safety Evaluation of Nanomaterials, Part 6: Characterization of Nanoscale Particles for Toxicological Evaluation,” Toxicological Sciences, 90 (2), 296–303, 2006.
Krishna, V., Pumprueg, S., Lee, S-H., Zhao, J., Sigmund, W., Koopman, B., and *Moudgil, B., “Photocatalytic disinfection with titanium dioxide coated multi-wall carbon nanotubes,” Process Safety and Environmental Protection, 83 (B4), 393-397, 2005.