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Florian Rieder Laboratory

❮Inflammation & Immunity Florian Rieder Laboratory
  • Florian Rieder Laboratory
  • Principal Investigator
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Principal Investigator

Florian Rieder Headshot

Florian Rieder, MD

Staff
Email: riederf@ccf.org
Location: Cleveland Clinic Main Campus

Research


Biography

Dr. Rieder is an Associate Staff in the Department of Gastroenterology, Hepatology and Nutrition as well as an Investigator in the Department of Pathobiology at the Cleveland Clinic, Cleveland, OH.

Dr. Rieder’s clinical focus is Inflammatory Bowel Diseases (Crohn’s disease and Ulcerative colitis) and his area of interest has been appreciated through leadership roles or participation in several clinical guidelines. Dr. Rieder is internationally recognized for his work on intestinal fibrosis. He has published more than 60 articles and book chapters and serves on multiple committees, speakers’ panels, editorial boards and steering committees. Dr. Rieder received multiple awards, including the Fellowship Award of the Crohn’s and Colitis Foundation of America, the best abstract award of the American Gastroenterology Association and the Crohn’s and Colitis Foundation, the best poster award of the United European Gastroenterology Federation, three consecutive Excellence in Teaching Awards for exceptional teaching achievements at the Cleveland Clinic and three NIH awards (T32, P30 Pilot and K08).


Education & Professional Highlights

Education & Fellowships

Fellowship - Cleveland Clinic
Gastroenterology
Cleveland, OH USA
2016

Residency - Cleveland Clinic
Internal Medicine
Cleveland, OH USA
2012

Fellowship - Cleveland Clinic
Post Doc Research Fellow Pathobiology
Cleveland, OH USA
2010

Fellowship - Cleveland Clinic
Post Doc Research Fellow Gastroenterology & Hepatology
Cleveland, OH USA
2009

Fellowship - Harvard Medical School
Inflammatory Bowel Disease Research Fellowship
Boston, MA USA
2007

Medical Education - Ludwig-Maximilians-Universitat
Munich, Germany
2004

Graduate School - Ludwig-Maximilians-Universitat
Inflammatory Bowel Disease Therapy
Munich, Germany
2004

Professional Highlights
  • Chair, Section chair and panel member in Clinical consensus guidelines on Fibrostenosing Crohn’s disease, Ulcerative colitis and Crohn’s disease of the European Crohn’s and Colitis Organization
  • Associate Editor, Clinical and Translational Gastroenterology 
  • Associate Editor, BMC Gastroenterology
  • Chair, Y-ECCO
  • Excellence in Teaching awards, Cleveland Clinic
  • Research Awards, German Research Foundation and European Crohn’s and Colitis Organization
  • Fellowship Award, Crohn’s and Colitis Foundation of America
  • NIH-T32, P30 Pilot and K08 awards
  • Scientific Committee, European Crohn’s and Colitis Organization
  • Professional Education Committee, Crohn’s and Colitis Foundation of America
Certifications
  • Internal Medicine
  • Internal Medicine - Gastroenterology
Memberships
  • American College of Physicians
  • American Gastroenterology Association
  • American College of Gastroenterology
  • European Crohn’s and Colitis Organization
  • Crohn’s and Colitis Foundation of America
  • American Society for Gastrointestinal Endoscopy

Research

Research

The inflammatory bowel disease (IBD) course is highly heterogenous. Intestinal fibrosis causing clinically apparent stricture formation is a common feature of both entities of IBD, Crohn’s disease and Ulcerative colitis and leads to a significantly impaired quality of life in affected patients, intestinal obstruction as well as need for surgical intervention. This constitutes a major treatment challenge, suppression of inflammation and the emergence of stronger immunosuppressive medications can only minimally reduce the incidence and prevalence of fibrostenosing IBD and no specific anti-fibrotic therapy is available.

 

Fibrosis results from the response of gut tissue to the insult inflicted by chronic inflammation. The underlying fibrogenic mechanisms are complex and dynamic, involving multiple cell types, interrelated cellular events, and a large number of soluble factors. These features are shared across organs, such as liver, skin, kidney or heart. Owing to a breakdown of the epithelial barrier in IBD, luminal bacterial products leak into the interstitium and induce an innate immune response mediated by activation of both immune and non-immune cells. Damage-associated molecular patterns, intracellular components released by necrotic cells, can also induce mesenchymal cell activation and contribute to stricture formation. Fat wrapping around the bowel wall, the so-called ‘creeping fat’, typical of Crohn’s disease, can drive fibrogenesis through the release of free fatty acids that induce intestinal muscle cell proliferation. Clinical and experimental evidence indicates that once fibrosis is established it can progress independently of inflammation. The composition of the intestinal extracellular matrix, its mechanoproperties and matrix bound factors are dramatically altered in chronic gut inflammation and can actively promote fibrosis. Identification of the unique mechanisms of intestinal fibrogenesis should create a practical framework to target and blockade specific fibrogenic pathways.

 

Our group focusses on the discovery of novel mechanisms of intestinal fibrogenesis, the prediction of fibrostenosing disease courses and innovative ways to treat IBD patients with established strictures. For this purpose, we are using primary human cells, tissues and organ culture systems as well as novel animal models of intestinal fibrosis. We have established an IBD biomarker cohort and assess endoscopic techniques to treat fibrostenosing IBD.  

Our Team

Our Team

Suhanti Banerjee Headshot

Suhanti Banerjee

Lead Research Technologist
banerjs4@ccf.org

,

eliasm2@ccf.org

Idan Goren Headshot

Idan Goren, MD, PhD

Postdoctoral Fellow
goreni@ccf.org

Nita Hoxha, MBA

Research Coordinator III
hoxhan@ccf.org

Tariq Jamal Khan

Postdoctoral Fellow
khant5@ccf.org

Satya Kurada, MD

Clinical Fellow
kuradas@ccf.org

Jiannan Li

Postdoctoral Research Fellow
lij4@ccf.org

Jin Ma

Research Coordinator
maj@ccf.org

William Massey

Postdoctoral Fellow
masseyw2@ccf.org

Pranab Mukherjee, PhD

Project Staff
mukherp2@ccf.org

Amelia (Ngan) Nguyen

Research Associate
nguyenn8@ccf.org

Ronald Ottichilo

Research Coordinator
ottichr@ccf.org

Ankita Prasad

Research Technician
prasada2@ccf.org

Carla Rayan

Research Laboratory Program Manager
rayanc@ccf.org

Shinjini Singh

Research Coordinator II
singhs11@ccf.org

Jie Wang, PhD

wangj7@ccf.org

Gail West

Principal Research Technologist
westg@ccf.org

Shuai Zhao, MS

Research Technologist
zhaos@ccf.org

Publications

Selected Publications

View publications for Florian Rieder, MD
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)


Rieder F., Cheng L., Harnett K.M., Chak A., Cooper G.S., Isenberg G., Ray M., Katz J.A., Catanzaro A., O`Shea R., Post A., Wong R., Sivak M.V., McCormick T., Phillips M., West G.A. Willis J.E., Biancani P., Fiocchi C. GERD-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Gastroenterology (2007) 132:154-65

Rieder F., Brenmoehl J., Artinger M., Georgieva M., Obermeier F., Rogler G. Prostaglandin E2 reduced migration of intestinal myofibroblasts. Inflamm Bowel Dis (2010) 16:1505-13

Rieder F., Kessler S., West G.A., Bhilocha S., dela Motte C., Saddler T.M., Gopalan B., Stylianou E., Fiocchi C. Inflammation-induced Endothelial-to-Mesenchymal Transition: A Novel Mechanism of Intestinal Fibrosis. Am J Path (2011) 5:2660-73

Rieder F., Nonevski I., Ma J., Ouyang Z., West G., Protheroe C., DePetris G., Schirbel A., Lapinski J., Goldblum J., Bonfield T., Lopez R., Harnett K., Lee J., Hirano I., Falk G.W., Biancani P., Fiocchi C. Th2 Cytokines, TGF-b1 and eosinophil products induce fibrogenesis and alter muscle motility in eosinophilic esophagitis. Gastroenterology (2014) 5:1266-77

Rieder F., Fiocchi C., Rogler G. Mechanisms, Management and Treatment of Fibrosis in Patients with Inflammatory Bowel Diseases. Gastroenterology (2017) 2: 340-50

Research News

Research News

...
The STAR Consortium Awarded $5.3 Million from the Helmsley Charitable Trust to Develop Next Generation Biomarker Tools for Crohn’s Disease Patients

The STAR consortium, led by coordinating PI Dr. Rieder, seeks to identify and develop novel biomarkers to help establish effective therapeutics for Crohn’s disease patients with fibrosis.



...
NIH Awards Grant to Study Creeping Fat and Develop Crohn’s Disease Treatments

Dr. Rieder seeks to identify new mechanisms responsible for fibrosis and stricture formation that leads to the development of novel preventive and therapeutic treatments for Crohn’s disease.



...
Florian Rieder Honored for IBD Research and Care With Sherman Prize



...
Helmsley Trust Awards $4.3M for Crohn’s Disease Research



...
New LRI Co-Laboratories Announced



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