Program lead: Nicolas Piuzzi
The vision of the Cleveland Clinic Adult Joint Reconstruction Research (CCARR) Program is to advance personalized patient care through evidence-based orthopedic practice and meaningful research. CCARR focuses on six strategic areas: (1) Personalized total joint arthroplasty (TJA) outcomes; (2) Robotic surgery and technology; (3) Revision TJA; (4) Periprosthetic joint infection (PJI); (5) Joint preservation and orthobiologics; and (6) Basic science/translational research related to Biofilm and PJI. Our program aims to identify key factors affecting outcomes in primary and revision TJA procedures. Through extensive basic, translational, and clinical research, we strive to enhance personalized clinical decision-making, patient and disease phenotyping, and the management of socioeconomic and disease-related factors, used to refine surgical techniques and care pathways. Our research directly translates to clinical practice, focusing on hip and knee procedures for osteoarthritis, osteonecrosis, arthrofibrosis, osteolysis, periprosthetic infections, and fractures. CCARR is committed to advancing personalized medicine, utilizing advanced analytical AI for outcome prediction, and developing programmatic research to innovate and create impactful solutions. Recognized as a world leader in arthroplasty research, the program publishes over 100 peer-reviewed manuscripts annually and conducts more than 10 clinical trials.
Collaborators: Anabelle Visperas, Matthew Deren, Viktor Krebs, Robert Molloy, Michael Bloomfield, John McLaughlin, Trevor Murray, Alexander Roth, Peter Surace, Nicholas Scarcella, Kim Stearns, Carlos Higuera-Rueda, Thaddeus Stappenbeck, Suneel Apte, Weiqiang Chen, Suan Sin Foo
Program leads: Kathleen Derwin, Eric Ricchetti
The Shoulder Research Program focuses on Arthroplasty and Rotator Cuff Repair surgery. Through laboratory and human subjects research, we seek to identify demographic, disease-related, biological and surgical factors associated with short- and longer-term outcomes following shoulder arthroplasty or rotator cuff repair, in both the primary and revision setting. We develop advanced imaging metrics to quantify baseline pathology, structural healing, and postoperative implant position (arthroplasty), along with treatments to improve implant longevity (arthroplasty) and tendon healing (rotator cuff repair). This includes a better understanding of factors that impact outcomes in revision shoulder arthroplasty, particularly periprosthetic joint infection, and the use of biological and structural augmentation strategies for rotator cuff repair. Our aim is to enhance patient outcomes by improving clinical decision-making, patient selection, proactive management of social and disease-related factors and optimizing surgical methods that maximize surgical healing.
Collaborators: Joseph Iannotti, Vahid Entezari, Jason Ho, Carl Winalski, Joshua Polster, Peter Imrey, Sambit Sahoo
Program leads: Lukas Nystrom, Zachary Burke
The Orthopaedic Oncology Research Program studies primary bone sarcoma, soft tissue sarcoma, metastatic bone disease and benign bone and soft tissue neoplasms. We have a clinical research group, directed by Lukas Nystrom, and a translational science research group, directed by Zachary Burke. We work in a very collaborative environment which spans multiple oncologic specialties including medical and radiation oncology, as well as pathology and radiology. Our aim is to advance the care of patients with these conditions through better understanding of their clinical behavior and clinical outcomes, as well as through understanding their biologic behavior.
Collaborators: Nathan Mesko, Shauna Campbell, Jacob Scott, John Reith, Scott Kilpatrick, Karen Fritchie, Josephine Dermawan, Hakan Ilaslan, Dale Shepard, Joseph Wooley, Matteo Trucco
Program lead: Heather Vallier
The Orthopaedic Trauma Research Program strives to improve our care for people with musculoskeletal injuries. We perform clinical, epidemiological, and outcomes research, routinely collaborating with other institutions in the United States and worldwide. Current interests include factors associated with improved fracture healing, mitigation of risks of complications, and optimization of physical and psychological outcomes following injury. We prospectively collect standardized surveys to assess extremity-specific and generalized musculoskeletal function and to evaluate various aspects of mental health and resilience. We further aspire to better understand the economic impacts of injury and its treatment so that we can enhance trauma care via cost-effectiveness.
Collaborators: Damien Billow, Cesar Cereijo, Anokha Padubidri, Brendan Patterson