The Inflammatory Arthritis research program focuses on biomarker discovery and novel imaging platforms to 1) establish early disease of immune mediated inflammatory arthritis, 2) improve stratification of patients with regard to disease burden and prognosis, and 3) improve upon therapeutic options to personalize treatment over the existing trial and error approach. To this end, we have built several disease specific biorepositories which contains over 15,000 samples to date. This biobank provides a valuable, ample resource for the investigation of mechanisms of disease, targeted therapeutics and identifying comorbidities associated with these conditions as well as discovery and validation of candidate biomarkers. Furthermore, we are refining imaging techniques in this patient population to allow for early detection of inflammatory changes as well as detecting active disease. Point-of-care novel imaging will enable future research on earlier diagnostic methods, identifying associated comorbidities, and improved treatment algorithms for immune mediated chronic inflammatory arthritis.
Research Program Faculty:
Elaine Husni, MD, MPH
Georgeanne Botek, DPM
Unni Chandrasekharan, PhD
Soumya Chatterjee, MD,FRCP
Jianguo Cheng, MD, PhD
Ceylan Colak, MD
Jason Genin, DO
Xiaojuan Li, PhD
Brian Mandell, MD, PhD
Sirada Panupattanapong, MD
Dominic Pelle, MD
Angela Robinson, MD
Carl Winalski, MD
Andrew Zeft, MD
The Post-traumatic Osteoarthritis research program focuses on identifying novel 'biomarkers' (risk factors) that provide reliable early diagnosis and prognosis of post-traumatic osteoarthritis (PTOA) development after joint injuries. Our multidisciplinary team investigates cohorts of human subjects as well as laboratory models of PTOA, using clinical and patient-reported outcomes, clinical and advanced quantitative imaging, gait analysis and biomechanical modeling. Conventional multivariate analysis as well as machine learning techniques are used to build models that predict long-term outcomes after injury and non-surgical or surgical interventions. By identifying modifiable predictors of PTOA development after joint injuries or surgery, our goals are to provide guidance for future development of novel interventions to reduce and prevent PTOA, help clinicians stratify subjects with regard to their individual risk of developing PTOA and improve clinical care in a directed and evidence-based way for this young and active population.
Research Program Faculty:
Xiaojuan Li, PhD
Suneel Apte, DPhil
Elise Baron, DEng
Gerald Beck, PhD
Jill Beveridge, PhD
Jianguo Cheng, MD, PhD
Ceylan Colak, MD
Robb Colbrunn, DEng
John Elias, PhD
Ahmet Erdemir, PhD
Lutul Farrow, MD
Jason Genin, DO
Peter Imrey, PhD
Atul Kamath, MD
George Muschler, MD
Nancy Obuchowski, PhD
Tammy Owings, DEng
Richard Parker, MD
Dominic Pelle, MD
Joshua Polster, MD
Kurt Spindler, MD
Naveen Subhas, MD
Carl Winalski, MD
The Degenerative (Primary) Osteoarthritis research program focuses on understanding primary osteoarthritis at a basic level. Many features of osteoarthritis are similar in all patients. However, individual patients vary widely in the severity and underlying cause of joint degeneration. This personalize approach guides our work in developing novel approaches for diagnosis, patient assessment and treatment. We integrate several disciplines to prevent or delay the progression of the disease, and work on options for both surgical and non-surgical treatments. Our aim is to find treatments that prevent arthritis and restore joint function. Our team integrates basic science, translational and clinical research. This begins with novel tools for measurement of stem cells and progenitors, non-invasive structural and functional imaging, and molecular tools that illuminate the physiopathology and biomechanical factors that control joint development, healthy joint function and the onset and progression of disease.
Research Program Faculty:
George Muschler, MD
Suneel Apte, DPhil
Jill Beveridge, PhD
Gary Calabrese, DPT
Jianguo Cheng, MD, PhD
Ceylan Colak, MD
Robb Colbrunn, DEng
Mitali Das, PhD
John Elias, PhD
Ahmet Erdemir, PhD
Jason Genin, DO
Kush Goyal, MD
Jason Ho, MD
Atul Kamath, MD
Michael Kattan, PhD
Dominic King, DO
Xiaojuan Li, PhD
Anthony Miniaci, MD
Nancy Obuchowski, PhD
Richard Parker, MD
Dominic Pelle, MD
Nicolas Piuzzi, MD
Carl Winalski, MD
The Arthroplasty research program focuses on identifying the demographic, disease-related, and surgical factors associated with short- and longer-term clinical outcomes following joint arthroplasty of the hip, knee, and shoulder, including potentially modifiable factors.Our approach utilizes both retrospective and prospective arthroplasty cohorts at our institution to allow for investigation of both short and longer-term clinical outcomes in primary and revision arthroplasty surgery. Our aim is to advance clinical outcomes and implant survivorship in total joint arthroplasty, by improving clinical decision-making, patient selection, proactive management of social and disease-related variables, and by optimizing surgical methods and processes. We have developed and utilize unique research tools to achieve this aim, including synovial fluid biomarker analysis in the setting of periprosthetic joint infection and post-operative three-dimensional CT imaging analysis of implant position over time. Our research program involves collaboration of faculty across orthopaedic surgery, biomedical engineering, radiology, pathology, and biostatistics.
Research Program Faculty:
Eric Ricchetti, MD
Jarrod Dalton, PhD
Kathleen Derwin, PhD
Vahid Entezari, MD
Ahmet Erdemir, PhD
Carlos Higuera, MD
Joseph Iannotti, MD, PhD
Peter Imrey, PhD
Bong-Jae Jun, PhD
Jason Ho, MD
Atul Kamath, MD
Michael Kattan, PhD
George Muschler, MD
Luke Nystrom, MD
Leonardo Oliveira, MD
Richard Parker, MD
Nicolas Piuzzi, MD
Sambit Sahoo, MD, PhD
Jonathan Schaffer, MD, MBA
William Seitz, MD
Naveen Subhas, MD
The Fracture Repair program focuses on identifying the effects of metabolic disease, chronic unloading and weightlessness, and the systemic and local biologic factors that influence the rate and extent of bone healing. It seeks to better understand and optimize new biologics and non-invasive biophysical treatments to promote better bone quality and augment fracture healing. The major tools used to assess bone healing in animal models are in vivo micro-CT and micro-MRI imaging, bone histomorphometry to assess bone cell populations and their functional activities, biomechanical testing to assess mechanical strength and healing extent, and correlation of all these outcome measures with one another to evaluate functional relationships. We utilize primary cultures of bone- or fracture callus-derived cells for culture experimentation to assess cellular and molecular mechanisms, and bone marrow derived connective tissue progenitors (CTPs) to assess osteochondral capabilities.
Research Program Faculty:
Damien Billow, MD
Robb Colbrunn, DEng
John Elias, PhD
Atul Kamath, MD
George Muschler, MD
William Seitz, MD
The Osteoporosis research program focuses on the loss of bone structure and function due to metabolic dysregulation of bone remodeling. Basic research focuses on developing new therapies to stop this loss of bone structure and function. Clinical care in the Center for Osteoporosis and Metabolic Bone Diseases reviews more than 12,000 bone densities every year to identify patients with low bone mass that might require treatment. Bone density results have been integrated into the electronic medical record to identify at risk patients for fracture. The Center has been involved in national and international clinical trials of drugs including anabolic agents, antiresorptive agents, and combination therapies. The Center participated in trials assessing bisphosphonate holidays, and costs and utilities related to osteoporotic fractures. Quality improvement projects are ongoing to better evaluate and treat osteoporosis patients. The Center has an ongoing interest in identifying patients with hypophosphatasia, a genetic condition with bone and musculoskeletal manifestations.
Research Program Faculty:
Chad Deal, MD
Abby Abelson, MD, FACR
Damien Billow, MD
Kush Goyal, MD
Michael Kattan, PhD
Sarah Keller, MD
Xiaojuan Li, PhD
George Muschler, MD
Leonardo Oliveira, MD
Ellen Rome, MD, MPH
The Program for Advanced Musculoskeletal Imaging (PAMI) is built upon Cleveland Clinic's nationally-ranked clinical care and research programs in orthopaedics, rheumatology and imaging. Our mission is to advance musculoskeletal imaging for improved orthopaedic and rheumatologic healthcare through technical development, clinical translation, and education. Novel imaging and image processing techniques are being developed and validated for improved structural, biochemical, and functional assessment of musculoskeletal tissues (cartilage, bone, tendon, ligament, muscle, fat, etc.). PAMI also strives for rapid clinical translation of state-of-the-art imaging techniques into routine clinical use to improve early diagnosis and prognosis for patients with significant musculoskeletal diseases. In addition to technical development, PAMI has a particular emphasis combining quantitative imaging, advanced data analysis methodologies (including big data analysis) and machine learning techniques. PAMI embraces all imaging modalities including MR (3T and 7T), CT, nuclear medicine and ultrasound.
Research Program Faculty:
Xiaojuan Li, PhD
Carl Winalski, MD
Faysal Altahawi, MD
Charlie Androjna, DEng
Elise Baron, DEng
Jill Beveridge, PhD
Ceylan Colak, MD
Frank DiFilippo, PhD
Vahid Entezari, MD
Jason Genin, DO
Michael Forney, MD
Hakan Ilaslan, MD
Bong Jae Jun, PhD
Stephen Hatem, MD
Atul Kamath, MD
Vladimir Kepe, PhD
Venkata Mantripragada, PhD
Kunio Nakamura, PhD
Joshua Polster, MD
Sambit Sahoo, MD,PhD
Jean Schils, MD
Wanyong Shin, PhD
Naveen Subhas, MD
Mingrui Yang, PhD
The Neuromuscular Disease research program focuses on disorders, degeneration and injury of the nervous system and the musculoskeletal system, and how deficits in one impact operation of the other. Our group explores relationships between the nervous system, muscles, and bones, including sensorimotor control, movement patterns, coordination, dexterity, and pain. Through better understanding of these relationships, we seek to develop interventions and improve diagnosis in a variety of conditions such as Parkinson's disease, multiple sclerosis, concussion, limb loss, diabetes, and cartilage and ligament injuries. We analyze healthy and impaired populations using motion analysis, ultrasound imaging, magnetic resonance imaging, electromyography, electroencephalography, and psychophysical techniques to understand how various conditions affect movement, control, and sensory feedback. Computational modeling helps characterize pathology as well as the influence of surgical and rehabilitation interventions. In addition, we incorporate technologies, such as robotic devices and deep brain stimulation, into treatments and quantify resulting benefits to patient health and quality of life.
Research Program Faculty:
Paul Marasco, PhD
Jay Alberts, PhD
Jill Beveridge, PhD
John Elias, PhD
Ghaith Habboub, MD
Dominic Pelle, MD
The Cleveland Clinic Center for Spine Health, a major center for spine-related treatment and research, is on the forefront of developing new technologies and collaborative approaches for effectively managing back and neck disorders. In addition to participating in several clinical trials, research at our center is focused on understanding patient-reported outcomes to learn how spine diseases and treatments are affecting patients' quality of life and using large databases to study the characteristics of spine patients as well as global trends in the delivery of spine care. Another large part of our research is aimed at employing different aspects of artificial intelligence to provide improve patient care and minimize cost for several health conditions, including spinal disorders.
Research Program Faculty:
Thomas Mroz, MD
Kush Goyal, MD
Ghaith Habboub, MD
Dominic Pelle, MD
Michael Steinmetz, MD
Orthopedic oncologic pathology involves collaboration among surgeons, radiologists, radiation oncologists, and medical oncologists. We actively seek to investigate and define both the clinicopathologic features of existing neoplasms (and variants) and entirely new entities, within the musculoskeletal system and skin/subcutaneous tissues. Our group have been instrumental in describing and further clarifying a variety of novel and recently dilenated neoplasms, including atypical sclerosing osteoblastic tumor, malignant chondroblastoma, YAP1-TFE3 hemangioendothelioma, superficial ALK-rearranged myxoid neoplasm, and EWSR1-SMAD3 fibroblastic tumor. Investigation of immunohistochemistry and molecular characteristics, including novel gene rearrangements, is ongoing.
Research Program Faculty:
Brian Rubin, MD
Steven Billings, MD
Karen Fritchie, MD
John Goldblum, MD
Scott Kilpatrick, MD
Nate Mesko, MD
Luke Nystrom, MD
John Reith, MD
In orthopedic pathology, especially recently, investigation of non-neoplastic diseases and their respective specimens have been often neglected by the pathology community. Our focus has been twofold: 1) re-evaluating the demographic, clinical, radiologic, and pathologic characteristics of a range non-neoplastic orthopedic diseases and specimens. 2) re-assessing the importance of histologic examination of routine orthopedic specimens on patient care and quality assurance. Over the past couple of decades, based largely on older studies, pathologic examination of joint resections has been decreasing at many institutions due to the perception of limited costeffectiveness relative to clinical information gained. Data from more recent studies, including our own, involving larger numbers of patients where pathologic examination remains routinely and meticulously performed, have challenged this concept, showing benefits to patient care and quality assurance/safety perspectives. Establishing an accurate and reliable diagnosis of avascular necrosis and calcium pyrophosphate dihydrate disease (pseudogout) requires pathologic examination, as predisposing clinical features are frequently absent and radiographs often misleading. Our current investigation into pathologic examination and diseases uncovered in arthroplasties continues, and we have expanded our research efforts into the pathologic evaluation of revision arthroplasties. Multidisciplinary studies with cardiology, orthopedics, and pathology have and currently are evaluating the incidence and significance of amyloid detection in a variety of routine, seemingly insignificant, orthopedic specimens obtained from surgeries related to carpal tunnel, trigger finger, and spinal ligamentum flavum.
Research Program Faculty:
Scott Kilpatrick, MD
Peter Evans, MD, PhD
Steven Maschke, MD
John Reith, MD
William Seitz Jr., MD
David Shapiro, MD
The Regenerative Therapies research program is focused on advancing patient care through development of new strategies for preservation, repair, regeneration, augmentation, or replacement of musculoskeletal tissues. Our ongoing health requires continuous renewal of the cells and tissues that we lose to degeneration, injury or disease. Regenerative Therapies integrate cells, scaffolds, environmental signals, nutritional support and/or mechanical stimuli into effective biologic therapies. All new strategies require detailed critical evaluation in the laboratory, as well as rigorous, honest, objective and critical assessment in patients, before they can be confirmed as safe, effective, and useful in improving our patient's health and lives. To accomplish this goal we have founded the Cleveland Clinic Joint Preservation Center (JPC). The JPC integrates clinical expertise in the emerging field of cellular and other biological therapies, in an environment of careful measurement, partnering with our patients to advance the future of musculoskeletal care.
Research Program Faculty:
George Muschler, MD
Mitali Das, PhD
Srinivasan Dasarathy, MD
Jason Genin, DO
Kush Goyal, MD
Carlos Higuera, MD
Elaine Husni, MD, MPH
Atul Kamath, MD
Dominic King, DO
Venkata Mantripragada, PhD
Leonardo Oliveira, MD
Nicolas Piuzzi, MD
Sambit Sahoo, MD, PhD
Carl Winalski, MD
Massarat Zutshi, MD
The Rotator Cuff Disease and Repair research program focuses on identifying the demographic, disease, and surgical factors, as well as local biologic factors such as stem and progenitor cell characteristics and inflammatory biomarkers, which influence healing and clinical outcomes following rotator cuff repair. Our aim is modification of key factors, either pre-operatively or through surgical treatment, leading to better clinical decision making, patient selection and improved outcomes. We also investigate extracellular matrix (ECM) scaffold technologies as a surgical treatment strategy for enhancing healing following rotator cuff repair. We utilize traditional MRI together with novel CT based imaging of radiopaque markers to measure tendon retraction and understand the relationship between structural healing of the tendon and clinical outcomes following rotator cuff repair. Further, we are currently developing imaging biomarkers to quantify local bone marrow 'quality' and guide decision-making about tissue healing potential and the need for cell-based therapies.
Research Program Faculty:
Kathleen Derwin, PhD
Ceylan Colak, MD
Vahid Entezari, MD
Ahmet Erdemir, PhD
Lutul Farrow, MD
Jason Genin, DO
Joseph Iannotti, MD, PhD
Peter Imrey, PhD
Bong-Jae Jun, PhD
Jason Ho, MD
Xiaojuan Li, PhD
Jinjin Ma, PhD
George Muschler, MD
Leonardo Oliveira, MD
Nicolas Piuzzi, MD
Joshua Polster, MD
Eric Ricchetti, MD
Sambit Sahoo, MD, PhD
Mark Schickendantz, MD
Alfred Serna, MD
Carl Winalski, MD
NIH (NINDS) — R01NS073717
Alberts, Jay
“The Cyclical Lower-Extremity Exercise (CYCLE) for Parkinson’s Trial”
NIH (NIAMS) — R01AR068342
Derwin, Kathleen / Iannotti, Joseph
“Failure with Continuity and its Relation to Rotator Cuff Repair Clinical Outcomes”
NIH (NIAMS) — R01AR077452
Li, Xiaojuan
“Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry”
NIH (NIAMS) — R01AR074131
Spindler, Kurt
“BEAR-MOON: A Two Arm Noninferiority Blinded Randomized Clinical Trial Comparing ACL Repair with BEAR Device vs. Standard of Care Autograft Patellar Tendon ACL Reconstruction”
NIH (NIAMS) — R01AR075422
Li, Xiaojuan
“Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI”
NIH (NICHD) — K01HD092556
Linder, Susan
“Cost-effectiveness and efficacy of a combined intervention to facilitate motor recovery following stroke”
NIH (NIAMS) — R21AR078401
Derwin, Kathleen
“Variation in Humeral Head Bone Marrow Characteristics and Their Associations with Rotator Cuff Repair Healing”
NIH (NIAMS) — R01AR055557 (sub-award)
Spindler, Kurt
“Partial Meniscectomy versus Nonoperative Management in Meniscal Tear with OA: An RCT”
NIH (NINDS) — U01NS113851 (sub-award)
Alberts, Jay
“Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3”
NIH (NIAMS) — U01AR080377 (sub-award)
Piuzzi, Nicolas
“HIP ATTACK-2 trial (HIP fracture Accelerated surgical care and TreaTment trACK) 2”
$10.4 Million
Total Grant Funding (2022)
NIH (NCCIH) — R01AT011905
Marasco, Paul
“Sensing active movement of the self: reconsidering the cellular basis kinesthesia”
NIH (NIAMS) — R01AR073225
Streubel, Philipp
“3D bioprinting of biomimetic constructs for rotator cuff augmentation”
NIH (NIBIB) — R01EB025212
Erdemir, Ahmet
"Software for Practical Annotation and Exchange of Virtual Anatomy"
NIH (NIDCR) — R01DE029634
Muschler, George
"Understanding and Using Variation in Source Materials for MSC Fabrication"
NIH (NIAMS) — R01AR077452
Li, Xiaojuan
"Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry"
NIH (NIAMS) — R01AR075422
Li, Xiaojuan
"Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI"
NIH (NIAMS) — R01AR068342
Derwin, Kathleen / Iannotti, Joseph
"Failure with Continuity and its Relation to Rotator Cuff Repair Clinical Outcomes"
NIH (NINDS) — R01NS073717
Alberts, Jay
"CYClical Lower Extremity exercise for Parkinsons trial (CYCLE Trial)"
NIH (NIAMS) — R01AR074131
Spindler, Kurt
"BEAR-MOON: A Two Arm Noninferiority Blinded Randomized Clinical Trial Comparing ACL Repair with BEAR Device vs. Standard of Care Autograft Patellar Tendon ACL Reconstruction"
NIH (NIAMS) — R01AR075286
Ricchetti, Eric
"Identifying the Patient, Disease, Surgical, and Implant Positional Shift Factors that Predict Outcomes Following Total Shoulder Arthroplasty"
NIH (NIAMS) — R13AR076258
Spindler, Kurt
"Clinician Scholar Career Development Program (CSCDP)"
NIH (NIAMS) — R21AR078498
Apte, Suneel
“The proteolytic landscape of osteoarthritic cartilage”
NIH (NIAMS) — R21AR078401
Derwin, Kathleen
“Variation in Humeral Head Bone Marrow Characteristics and Their Associations with Rotator Cuff Repair Healing”
NIH (NINDS) — R21NS129147
Alberts, Jay
“The impact of exercise on subthalamic nucleus neural activity in Parkinson's disease”
NIH (NICHD) — K01HD092556
Linder, Susan
“Cost-effectiveness and efficacy of a combined intervention to facilitate motor recovery following stroke”
NIH (NIAMS) — K25AR078928
Yang, Mingrui
“Automated Arthroscopic Partial Meniscectomy Patient Outcome Prediction using Deep Learning”
NIH (NIAMS) — R01AR055557 (sub-award)
Spindler, Kurt
“Partial Meniscectomy vs. NonOperative Management in Meniscal Tear with OA: An RCT”
NIH (NIAMS) — U01AR080377 (sub-award)
Piuzzi, Nicolas
“HIP ATTACK-2 trial (HIP fracture Accelerated surgical care and TreaTment trACK) 2”
NIH (NINDS) — U01NS113851 (sub-award)
Alberts, Jay
"Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3"
2015–2019 | 2020 | 2021 | 2022 | Cumulative | |
---|---|---|---|---|---|
Invention disclosures | 86 | 12 | 17 | 24 | 115 |
Patent applications | 63 | 9 | 10 | 13 | 82 |
Patents granted | 93 | 15 | 15 | 3 | 123 |
Assell R, Freeman A, Muschler GF: “Bone fragment and tissue harvesting system”. US Patent No: 11,337,710; granted May 2022.
Baker JJ, Gingras PH, Priest R, Derwin K, Iannotti JP, Sahoo S, Baker AR: “Radiopaque tissue marker”. US Patent No: 11,413,112; granted Aug 2022.
Schoenhagen P, Chen PH, Piraino D, Obuchowski N: “Automated identification of acute aortic syndromes in computed tomography images”. US Patent No: 11,475,561; granted Oct 2022.
Assell R, Freeman A, Muschler G: “Bone void filler preparation system”. US Patent No: 10,953,134; granted Mar 2021.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill PD: “System of preoperative planning and provision of patient-specific surgical aids”. US Patent No: 10,973,535; granted Apr 2021.
Derwin KA, Iannotti JP, Sahoo S: “Reinforced tissue graft”. US Patent No: 11,013,590; granted May 2021.
Muschler GF, Monnich JK, Kwee EJ, Powell KA, Herderick EE, Boehm CA, Adams TR, Germanoski R, Krakosh III F, Dunn J, Bantz D: “Systems and methods for detection, analysis, isolation and/or harvesting of biological objects”. US Patent No: 10,564,172; granted Feb 2020.
Schindler DD, Alberts JL, Hirsch JR: “Systems and Methods to Assess Balance and Stability”. US Patent No: 10,588,546; granted Mar 2020.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill PD: “System and Method for Association of a Guiding Aid with a Patient Tissue”. US Patent No: 10,624,655; granted Apr 2020.
Assell R, Freeman A, Muschler GF: “Bone Fragment and Tissue Harvesting System”. US Patent No: 10,610,242; granted Apr 2020.
Alberts JL, Bermel R, Rao S, Schlinder DD: “Assessment of Low Contrast Visual Sensitivity”. US Patent No: 10,667,682; granted Jun 2020.
Alberts JL, McIntyre C: “System and Method for Motor and Cognitive Analysis”. US Patent No: 10,741,287; granted Aug 2020.
Derwin K, Aurora A, Iannotti JP, McCarron, JA: “Reinforced Tissue Graft”. US Patent No: 10,758,644; granted Sep 2020.
Cheng J: “Devices and Methods for Treating Medical Conditions Associated with Sacroiliac Joint Abnormalities”. US Patent No: 10,849,708; granted Dec 2020.
Alberts JL, Schindler DD: “Object Recognition by Touch Screen”. US Patent No: 10,206,609; granted Feb 2019.
Iannotti JP, Barsoum WK, Bryan JA: “System and Method for Assisting with Attachment of a Stock Implant to a Patient Tissue”. US Patent No: 10,258,352; granted Apr 2019.
Iannotti JP, Barsoum WK, Bryan JA: “Apparatus and Method for Providing a Reference Indication to a Patient Tissue”. US Patent No: 10,307,174; granted Jun 2019.
Assell R, Freeman A, Muschler G: “Bone Fragment and Tissue Processing System”. US Patent No: 10,342,552; granted Jul 2019.
Derwin KA, Iannotti JP, Milks RA: “Devices and Methods for Tissue Graft Delivery”. US Patent No: 10,383,657; granted Aug 2019.
Alberts JL, Schindler DD, Rhodes J, Gabel W, Best J: “Apparatus and Related Method to Facilitate Testing Via a Computing Device”. US Patent No: 10,420,497; granted Sep 2019.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill P: “Alignment of Manipulable Sensor Assembly”. US Patent No: 10,456,062; granted Oct 2019.
Assell R, Freeman A, Muschler G: “Bone Void Filler Preparation System”. US Patent No: 10,456,502; granted Oct 2019.
Alberts JL, Rudick RA, Schindler DD, Hirsch J, Rao SM, Bethoux F, Linder S, Miller D: “Performance Test for Evaluation of Neurological Function”. US Patent No: 10,470,679; granted Nov 2019.
Iannotti JP, Barsoum WK, Bryan JA: “System and Method for Assisting with Arrangement of a Stock Instrument with Respect to a Patient Tissue”. US Patent No: 10,512,496; granted Dec 2019.
Alberts JL, Bermel R, Rao S, Schindler DD: “Assessment of Low Contrast Visual Sensitivity”. US Patent No: 10,028,653; granted Jul 2018.
Derwin KA, Calabro A: “Biocompatible Tissue Graft”. US Patent No: 10,004,586; granted Jun 2018.
Evans PJ, Trickett J: “Multipurpose Membranes, Methods for Forming, and Applications Thereof”. US Patent No: 10,086,110; granted Oct 2018.
Iannotti JP, Barsoum WK, Bryan JA: “System and Method for Assisting with Attachment of a Stock Implant to a Patient Tissue”. US Patent No: 9,877,735; granted Jan 2018.
Machado AG, Alberts JL, McIntyre C, Schindler DD: “Evaluation of Movement Disorders”. US Patent No: 10,028,695; granted Jul 2018.
Alberts JL: “System and Method to Facilitate Analysis of Brain Injuries and Disorders”. US Patent No: 9,610,029; granted Apr 2017.
Alberts JL, McIntyre CC: “Reversing Cognitive-Motor Impairments in Patients Having a Neuro-Degenerative Disease Using a Computational Modeling Approach to Deep Brain Stimulation Programming”. US Patent No: 9,776,003; granted Oct 2017.
Alberts JL, McIntyre CC: “System and Method for Motor and Cognitive Analysis”. US Patent No: 9,653,002; granted May 2017.
Alberts JL, Schindler DD: “Object Recognition by Touch Screen”. US Patent No: 9,737,242; granted Aug 2017.
Iannotti JP: “Prosthetic Articulation Surface Mounting”. US Patent No: 9,572,670; granted Feb 2017.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill PD: “System of Preoperative Planning and Provision of Patient-Specific Surgical Aids”. US Patent No: 9,741,263; granted Aug 2017.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill PD: “System of Preoperative Planning and Provision of Patient-Specific Surgical Aids”. US Patent No: 9,717,508; granted Aug 2017.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill PD: “System and Method for Association of a Guiding Aid with a Patient Tissue”. US Patent No: 9,615,840; granted Apr 2017.
Polster JM, Hoffman G: “Tissue Sampling Device”. US Patent No: 9,622,727; granted Apr 2017.
Derwin KA, Iannotti JP, Milks RA: “Devices and Methods for Tissue Graft Delivery“. US Patent No: 9,265,524; granted Feb 2016.
Iannotti JP: “Humeral Joint Replacement Component”. US Patent No: 9,512,445; granted Dec 2016.
Iannotti JP: “Prosthetic Articulation Surface Mounting”. US Patent No: 9,241,804; granted Jan 2016.
Iannotti JP, Barsoum WK, Bryan JA: “Apparatus and Method for Providing a Reference Indication to a Patient Tissue”. US Patent No: 9,326,781; granted May 2016.
Iannotti JP, Barsoum WK, Bryan JA: “System and Method for Assisting with Arrangement of a Stock Instrument with Respect to a Patient Tissue”. US Patent No: 9,254,155; granted Feb 2016.
Iannotti JP, Bonutti PM: “Methods and Devices for Bone Preparation”. US Patent No: 9,439,704; granted Sep 2016.
Iannotti JP, Williams G, Koka D, Hollis MC: “Glenoid Vault Fixation”. US Patent No: 9,439,768; granted Sep 2016.
Iannotti J, Williams G, Koka D, Hollis MC: “Shoulder Arthroplasty”. US Patent No: 9,414,927; granted Aug 2016.
Miniaci A, Fening SD, Hartzell BE: “Apparatus and Method for Sequentially Anchoring Multiple Graft Ligaments in a Bone Tunnel”. US Patent No: 9,339,370; granted May 2016.
Polster J: “Percutaneous Needle Guide and Method”. US Patent No: 9,381,035; granted Jul 2016.
Polster JM: “Method and Apparatus for Tissue Sampling”. US Patent No: 9,326,754; granted May 2016.
Alberts JL: “Systems and Methods for Improving Motor Function with Assisted Exercise”. US Patent No: 9,067,098; granted Jun 2015.
Fening SD, Miniaci A: “Apparatus and Method for Sequentially Anchoring Multiple Graft Ligaments in a Bone Tunnel”. US Patent No: 9,011,536; granted Apr 2015.
Iannotti JP, Barsoum WK, Bryan JA: “Apparatus and Method for Dictating at Least One of a Desired Location and a Desired Trajectory for Association of a Landmark with a Patient Tissue”. US Patent No: 9,198,732; granted Dec 2015.
Iannotti JP, Barsoum WK, Bryan JA: “Directed Structure Placement Guide”. US Patent No: 9,033,990; granted May 2015.
Iannotti JP, Barsoum WK, Bryan JA: “Positioning Apparatus and Method for a Prosthetic Implant”. US Patent No: 9,011,452; granted Apr 2015.
Iannotti JP, Barsoum WK, Bryan JA: “Apparatus and Method for Providing a Reference Indication to a Patient Tissue”. US Patent No: 8,992,539; granted Mar 2015.
Iannotti JP, Barsoum WK, Bryan JA: “Apparatus and Method for Transferring Predetermined Spatial Positioning Information to an Adjustable Tool”. US Patent No: 8,926,627; granted Jan 2015.
Iannotti JP, Bonutti PM: “Methods and Devices for Bone Preparation”. US Patent No: 9,216,046; granted Dec 2015.
Machado A, Alberts JL, McIntyre C, Schindler D: “Evaluation of Movement Disorders”. US Patent No: 9,186,095; granted Nov 2015.
Muschler G, Caralla T, Hascall V, Midura R: “Enrichment of Tissue-Derived Adult Stem Cells Based on Retained Extracellular Matrix Material”. US Patent No: 9,045,735; granted Jun 2015.
Polster JM: “Augmented Reconstruction for Computed Tomography”. US Patent No: 9,153,045; granted Oct 2015.
The Musculoskeletal Research Center's Pilot Project Program for Cleveland Clinic investigators is available to support currently unfunded, novel, particularly innovative, disease-oriented projects that are in need of the early data that would make them competitive for extramural funding. Funding will be available to support projects along the entire continuum of biomedical investigation, including discovery, translation and direct patient-involved research.
Two types of awards of up to $25,000 each are available: (1) MSRC General awards are for musculoskeletal research projects on any topic related to musculoskeletal research, and (2) MSRC MSK Imaging awards are for musculoskeletal imaging research projects. There are two annual funding cycles; deadlines for applications are March 15 and September 15 of each year.
InfoReady Review is used to manage Pilot Project submissions. Each competition will be launched on the InfoReady Review home page one month prior to the deadline. If you have any issues submitting an application, please contact us.
The Amy and David Krohn Family Orthopaedic Outcomes Center (OOC) is an arm of the Cleveland Clinic Musculoskeletal Research Center (MSRC) focusing primarily on the clinical outcomes of orthopaedic surgery and related treatments. Bringing together the expertise of orthopaedic clinicians, researchers, data scientists, and statisticians, the OOC endeavors to:
The OOC’s flagship service is the Outcomes Management and Evaluation (OME) system, which is used across the institution to systematically collect patient-reported outcome measures (PROMs) in a highly structured and consistent manner. OME is a cost-effective, scientifically valid, scalable electronic system for collecting PROMs and clinical information surrounding an episode of care:
Initially launched in 2015 an “Episode of Care” supplement to the OOC’s former OrthoMiDaS system, OME has since supplanted OrthoMiDaS to establish itself as the de-facto data collection mechanism for orthopaedic surgery. The data collected through this system feeds the OME Cohort, a powerful prospective cohort that supports standard of care, quality initiatives, and three primary points of research focus:
As of August 2019, OME is active at 16 Cleveland Clinic hospitals and ASCs and covers over 95% of elective orthopaedic surgery cases performed on the knee, hip, and shoulder, ranging from arthroscopy to arthroplasty. OME is also used in select spine, hand, wrist, foot, and ankle surgeries, as well as for patients receiving non-surgical orthobiologic treatment and patients undergoing MRI scans for sports injuries. Over 45,000 episodes of care representing over 40,000 patients have been collected to date with average baseline PROM completion rates of over 95% and 1-year follow-up PROM completion rates of over 70%. Additional orthopaedic and non-orthopaedic procedures are being added to the OME portfolio regularly.
Publication Tracker (FINER Form)
BEAR-MOON
Multicenter FDA trial funded by NIH/NIAMS comparing the BEAR® scaffold for ACL repair to standard of care ACL reconstruction
https://bearmoon.org
To become a member of the MSRC, please send an email to owingst@ccf.org.
MSRC Governance Board
MSRC Steering Committee
Lerner Research Institute
Orthopaedic & Rheumatologic Institute
Imaging Institute
Children's Hospital and Pediatrics Institute
Neurological Institute
Digestive Disease & Surgery Institute
Anesthesiology Institute
Pathology & Lab Medicine Institute
Respiratory Institute
Cleveland Clinic Akron General
Cleveland Clinic Florida