Careers

Job Description:

Associate Professor/Faculty Position in Immuno-oncology/Oncology at the Cleveland Clinic Florida Research and Innovation Center, Port St Lucie, FL

The Cleveland Clinic Florida Research and Innovation Center (CC-FRIC), Port St. Lucie, Florida, invites applications for one full-time position at the Associate Faculty level. The Position will be within the broad fields of immuno-oncology or molecular oncology.

CC-FRIC is dedicated to the discovery and advancement of innovative basic and translational research focused on infectious disease, immunobiology, and immuno-oncology/oncology. The Center has three floors with approximately 100,000 sq. ft. of dedicated research and support spaces including Shared Resource Facilities in Flow Cytometry, Imaging, Bioinformatics, and a Vivarium. This position offers co-appointment in Cleveland Clinic’s Center for Immunotherapy & Immuno-oncology (CITI) led by Timothy Chan, MD, PhD. Faculty at the CC-FRIC also closely collaborate with scientists at the Lerner Research Institute (LRI), a network of ~190 labs at Cleveland Clinic’s main campus in Ohio, and further, with physicians at the regional hospitals of Cleveland Clinic Florida.

Key requirements

Ideal applicants will be established faculty candidates at the assistant or associate professor level with at least 5 years of independent research experience and an outstanding record in immuno-oncology or molecular oncology. The selected candidates will possess scientific vision, leadership skills and be competitive in acquiring extramural grants. Basic requirements for the position are a Ph.D. or M.D.-PhD., as well as postdoctoral research experience and a strong record of research accomplishments and publications in the field of immuno-oncology/oncology.

Application Instructions

Please apply by sending your CV, a motivation letter, a project description and providing contacts of four potential referees. The project description should be a maximum of 3 pages long and describe both current and future research plans.

Please email application materials to:

Michaela U. Gack, Ph.D. (GACKM@ccf.org)
The Arthur and Marylin Levitt Endowed Chair
Scientific Director
Florida Research and Innovation Center
Port Saint Lucie, FL

Administrative Director: Anne Gambardella (GAMBARA@ccf.org)

Cleveland Clinic is pleased to be an equal employment/affirmative action employer: Women/Minorities/Veterans/Individuals with Disabilities. Smoke/drug free environment

Contact:

Michaela U. Gack, Ph.D.
gackm@ccf.org

Job Description:

Flow Cytometry Director

Cleveland Clinic Florida Research and Innovation Center (FRIC) is seeking a Flow Cytometry Director who can be part of a dynamic and rapidly growing organization. The candidate will need to have advanced technical and scientific expertise in flow cytometry and cell sorting, and the ability to work collaboratively with investigators in a BSL-2 and BSL-3 research facilities.  The candidate will operate all flow cytometry equipment, train users, consult on experimental design, data analysis, and interpretation and assist with the execution of experiments. Ideally, the candidate will serve as an expert resource for the implementation, management, and improvement of flow cytometry projects at FRIC. As one of the world’s largest and busiest health centers, Cleveland Clinic is committed to delivering high quality programs of patient care, research, and education.  Cleveland Clinic’s Lerner Research Institute (LRI) researchers are at the forefront of biological discovery with research related to cancer, cardiovascular and metabolic diseases, brain and eye diseases, and diseases of inflammation and immune systems. With more than 1,500 researchers and support personnel in 190 laboratories across 11 departments and multiple centers, the Lerner Research Institute is one of the largest research institutes in the nation, consistently ranking in the top 10 in National Institutes of Health funding, a benchmark of research success.  Additionally, the Lerner Research Institute has recently opened Cleveland Clinic Florida Research and Innovation Center (FRIC) which is dedicated to the discovery and advancement of innovative translational research, focused on immuno-oncology and infectious diseases.  The building is 3 floors with approximately 100,000 sq. ft. of dedicated research and support spaces.  The FRIC is developing state of the art Shared Resource Laboratories in Flow Cytometry, Imaging, Bioinformatics, and a Vivarium. 

As a Flow Cytometry Director, your responsibilities will be to:

• Operate and manage flow cytometry analyzers and cell sorters, including instrument QA/QC and scheduling.
• Supervise, mentor, and expertly train junior Core members.
• Train users for application-specific flow cytometry equipment operation in BSL2/3 environment.
• Advise users on experimental protocols, preparation of samples, analysis, and interpretation of data.
• Participate in grant and manuscript writing.
• Establish and maintain a flow cytometry and BSL2/BSL3 biosafety educational program for the user community.
• Write and implement lab policies and standard operating protocols.
• Responsible for the proper maintenance, alignment, calibration and troubleshooting of equipment for specific experimental requirements
• Stay abreast of current best practices and new technological developments in the field.
• Provide top-level customer service.
• Provide general oversight for the facility to the Director for Shared Resources.     

Work Experience:

• Demonstrated expertise in polychromatic immunophenotyping and cell sorting, including panel design, equipment operation, data analysis and interpretation, and troubleshooting.
• Demonstrated ability to advise and guide investigators in multiple research projects, and assist with manuscript and grant writing.
• Experience in overseeing operations in a Flow Cytometry Facility, and the ability to work independently.
• Experience in a BSL2/BSL3 environment is highly desirable.
• Excellent communication and analytical skills.

Education:

• Ph.D. with at least three years of experience in a Flow Cytometry Core Facility is preferred for an appointment at a Director level.
• Masters with at least six years of experience in a Flow Cytometry Core Facility
• Current ASCP Board Certification for Specialist in Cytometry is highly recommended.

Physical Requirements

• Visual acuity. The ability to distinguish colors.
• Manual dexterity to handle specimens and repair equipment.
• May be required to stand for long periods of time
• Light lifting may be required.
• This position requires candidates to obtain/maintain medical clearance through Cleveland Clinic’s Occupational Health Department to work in a Biosafety Level 3 Environment (BSL3).  Medical clearance including medical management is completed upon hire, transfer, and annually. This includes but is not limited to requirements for wearing respiratory protection.

Personal Protective Equipment:

• Follows standard precautions using personal protective equipment as required
• Ensures compliance and safety standards for BSL-2/3 environment

Please send all inquiries/CV to:

Sara Tavakoli, PhD
Director Research Compliance and Operations
Cleveland Clinic Florida Research and Innovation Center
Port St. Lucie, FL
tavakos@ccf.org

Cleveland Clinic is pleased to be an equal employment/affirmative action employer: Women/Minorities/Veterans/Individuals with Disabilities. Smoke/drug free environment.      

Contact:

Sara Tavakoli, PhD
tavakos@ccf.org

Job Description:

The Ross lab is seeking a highly motivated individual to join our Research team and help develop our antibody discovery pipeline. The role will be highly integrated with our Vaccine and Antibody team and will require background knowledge in antibody discovery / characterization platforms, particularly with respect to comparative sequence analysis and in silico modeling. General knowledge of how such analysis translates in antibody repertoire analysis is preferred. The role is central to our internal capabilities as our lab integrates its proprietary vaccine platform and antibody characterization capabilities. 

The ideal candidate will have previous hands-on experience with bioinformatics analysis of B-cell derived antibody sequence information and omics analysis with a proven track record of applying bioinformatic analysis for antibody drug discovery Meticulous attention to detail, proficient reasoning, and problem-solving skills are cornerstones for a successful candidate. 

 

This position will offer an outstanding opportunity to build a unique skillset at the interface of immunology and computational science, with an emphasis on efforts that have a high potential for ground-breaking discoveries for therapeutic and vaccine development.  

 

Responsibilities: 

• Perform antibody-based sequence analysis and report generation with large, high-dimensional data sets. 
• Identify potential antibody candidates for further expression, purification and characterization. 
• Customize software and analysis tools to generate functional data reports. 
• Develop new methods and optimize techniques that translate bioinformatic outputs to execution in the lab and guide subsequent downstream analysis. 

Preferred qualifications: 

• Ph.D. degree in biology, computational biology, bioinformatics or other related discipline with 2+ years relevant experience in data science and protein modeling and antibody analysis or M.S. in biology, computational biology, bioinformatics or other related discipline with 6+ years of experience in antibody analysis. 
• Strong knowledge of antibody biology and familiarity with antibody discovery workflows (e.g., LIBRA-seq or other antigen-specific antibody discovery pipelines) for therapeutics development. 
• Strong background in relevant research areas, such as microfluidics, single-cell sequencing, B cell immunology, protein production, structural biology, and bioinformatics will be a plus.  
• Demonstrated experience in software deployment and customization of existing software tools as it relates to protein and antibody bioinformatics. 
• Prior experience with antibody sequence analysis and protein modeling using bioinformatic tools. 
• Proven ability to efficiently compile and statistically analyze metadata in the biological field. 
• Excellent attention to detail, record keeping, and a passion for accuracy and precision. 
• Ability to work in a fast-paced lab with an intrinsically multi-disciplinary environment. 
• Strong writing/presenting skills. 

 

Please send CV and cover letter to Tristan Erdman ERDMANT@ccf.org 

 

Cleveland Clinic is pleased to be an equal employment/affirmative action employer: 
Women/Minorities/Veterans/Individuals with Disabilities. Smoke/drug free environment

Contact:

Tristan Erdman
ERDMANT@ccf.org

Job Description:

Bioinformatician - Florida Research & Innovation CenterCleveland Clinic Florida Research and Innovation Center (FRIC) is seeking a Bioinformatician who can be part of a dynamic and rapidly growing organization. The candidate will lead be responsible for the design and implementation of novel computational methods to analyze genomic data sets, implement statistical models, and contribute to research studies focusing on infectious disease and immuno-oncology. Ideally, the candidate will serve as an expert resource for the implementation, management, and improvement of bioinformatics projects at FRIC. As one of the world’s largest and busiest health centers, Cleveland Clinic is committed to delivering high quality programs of patient care, research, and education. Cleveland Clinic’s Lerner Research Institute (LRI) researchers are at the forefront of biological discovery with research related to cancer, cardiovascular and metabolic diseases, brain and eye diseases, and diseases of inflammation and immune systems. With more than 1,500 researchers and support personnel in 190 laboratories across 11 departments and multiple centers, the Lerner Research Institute is one of the largest research institutes in the nation, consistently ranking in the top 10 in National Institutes of Health funding, a benchmark of research success. In addition, Cleveland Clinic and IBM have a partnership to establish the Discovery Accelerator to advance discovery in healthcare and life sciences using a variety of computing technologies, including quantum computing. Additionally, the Lerner Research Institute has recently opened Cleveland Clinic Florida Research and Innovation Center (FRIC) which is dedicated to the discovery and advancement of innovative translational research, focused on immuno-oncology and infectious diseases. The building is 3 floors with approximately 100,000 sq. ft. of dedicated research and support spaces. The FRIC is developing state of the art Shared Resource Laboratories in Flow Cytometry, Imaging, Bioinformatics, and a Vivarium. As a Bioinformatician, your responsibilities will be to: Communicate with faculty members, postdocs and researchers to understand and evaluate their biological questions and computational needs to effectively provide consultation for a wide array of genomics studies. Support diverse bioinformatics analyses such as single-cell RNA-seq, bulk RNA-seq, ChIP-seq, methyl-seq, spatial transcriptomics etc. Develop methods, novel algorithms and/or high-level data analysis pipelines that integrates implementation, visualization and database management of multi-dimensional biological datasets. Provide researchers with computational data, figures, methods, documentation, and overall bioinformatics support to meet project goals and publications. Support analysis needs of multiple research projects form different laboratories simultaneously. Serve as a subject matter expert to provide training, mentoring and instruction to researchers on bioinformatics resources and data analysis. Utilize methods in the areas of Artificial Intelligence (AL), Machine Learning (ML), Deep Learning (DL), Natural Language Processing (NLP) to design and implement data solutions. Build complex predictive models, mix models, attribution models and other mathematical or statistical models as needed by using modeling tools.Stay up to date with cutting edge data analysis methods and publications in bioinformatics, genomics, and statistics. Develop service-related charge infrastructure for researchers utilizing bioinformatics services. Qualifications Education Ph.D. in computer science/statistics/software engineering/bioinformatics or related field. Work Experience Must possess a minimum of 3 years of related experience, working with statistical modeling, machine learning or complex data analysis. Strong quantitative and computational background with extensive experience in genomics/transcriptomics. Use of bioinformatics computations in high-performance compute clusters and bash scripting, and pipeline development and implementation. Proficient in R, Python, git, UNIX and other scientific workflow tools Physical Requirements Ability to perform work in a stationary position for extended periods Ability to operate a computer and other office equipment Ability to communicate and exchange accurate information Please send CV and cover letter to Sara Tavakoli at tavakos@ccf.org. 

Contact:

Sara Tavakoli
tavakos@ccf.org