Pregnancy is a nine-month biological process involving the complex network of immune rewiring, rendering it vulnerable to infectious diseases. As much as infection during pregnancy alters maternal immunity, long-term repercussion in the offspring immunity and development can occur through the process of fetal programming.
Dr. Foo’s research focuses on viral infection during pregnancy, specifically viral pathogenesis and maternal-fetal immunology. The primary research in the Foo lab focuses on elucidating the long-term immune repercussion in mother and child during prenatal infection by emerging pathogens including Zika virus and high-risk pathogen SARS-CoV-2. To address this, Dr. Foo’s lab will employ a “bench-bedside-bench” strategy, which includes a blend of molecular and immunological approaches using: (1) in vitro models – reverse genetic and whole blood infection system, (2) pre-clinical models – prenatal infections in immunocompetent mouse models, and (3) clinical models – using patients’ specimens from retrospective and prospective mother-infant dyads cohorts in collaborative efforts with an international team of infectious diseases clinician-researchers from Cleveland Clinic and other international institutions.
Coming soon.
Coming soon.
Dr. Foo’s research focuses on viral infection during pregnancy, specifically viral pathogenesis and maternal-fetal immunology. The primary research in the Foo lab focuses on elucidating the long-term immune repercussion in mother and child during prenatal infection by emerging pathogens including Zika virus and high-risk pathogen SARS-CoV-2. To address this, Dr. Foo’s lab will employ a “bench-bedside-bench” strategy, which includes a blend of molecular and immunological approaches using: (1) in vitro models – reverse genetic and whole blood infection system, (2) pre-clinical models – prenatal infections in immunocompetent mouse models, and (3) clinical models – using patients’ specimens from retrospective and prospective mother-infant dyads cohorts in collaborative efforts with an international team of infectious diseases clinician-researchers from Cleveland Clinic and other international institutions.
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Learn MoreDr. Jung’s team studied blood samples collected from mothers with COVID-19 and their infant children who were exposed to SARS-CoV-2 to understand how infection modulates the expression of different inflammatory molecules.