Research

Recent Inflammation & Immunity Publications

Adaptive Immunity

Water channel aquaporin 4 is required for T cell receptor mediated lymphocyte activation. Nicosia M, Lee J, Beavers A, Kish D, Farr GW, McGuirk PR, Pelletier MF, Lathia JD, Fairchild RL, Valujskikh A. J Leukoc Biol. 2023 Jun 1;113(6):544-554. doi: 10.1093/jleuko/qiad010. PMID: 36805947

Inflammation & Fibrosis

Topical N-phosphonacetyl-l-aspartate is a dual action candidate for treating non-melanoma skin cancer. Mahen KK, Markley L, Bogart J, Klatka H, Krishna V, Maytin EV, Stark GR, McDonald C. Exp Dermatol. 2023 Jun 13. doi: 10.1111/exd.14853. PMID: 37309615

Asthma innovations from the first International Collaborative Asthma Network forum. Gaston B, Gardner DD, Mahan K, Akuthota P, Mendonca EA, Durrington H, Marozkina N, Martinez-Nunez RT, Newcomb D, Ainsworth B, Owora AH, Chung KF, Walker S, Fowler SJ, Siddiqui S, Winders T, Zein J, Jarjour N, Huang YJ, Cahill KN, Djukanovic R.ERJ Open Res. 2023 May 30;9(3):00090-2023. doi: 10.1183/23120541.00090-2023. eCollection 2023 May. PMID: 37260461

Innate Host Defense

EGF Receptor-dependent TLR7 Signaling in Macrophages Promotes Glomerular Injury in Crescentic Glomerulonephritis. Tatsumoto N, Saito S, Rifkin IR, Bonegio RG, Leal DN, Sen GC, Arditi M, Yamashita M. Lab Invest. 2023 May 31:100190. doi: 10.1016/j.labinv.2023.100190. PMID: 37268107

Mucosal Biology & Epithelial Barriers

Single-cell transcriptomic profiling of microvascular endothelial cell heterogeneity in congenital diaphragmatic hernia. Robertson JO, Bazeley P, Erzurum SC, Asosingh K. Sci Rep. 2023 Jun 17;13(1):9851. doi: 10.1038/s41598-023-37050-y. PMID: 37330615

Early Initiation of Antitumor Necrosis Factor Therapy Reduces Postoperative Recurrence of Crohn's Disease Following Ileocecal Resection. Axelrad JE, Li T, Bachour SP, Nakamura TI, Shah R, Sachs MC, Chang S, Hudesman DP, Holubar SD, Lightner AL, Barnes EL, Cohen BL, Rieder F, Esen E, Remzi F, Regueiro M, Click B. Inflamm Bowel Dis. 2023 Jun 1;29(6):888-897. doi: 10.1093/ibd/izac158. PMID: 35905032

Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit Cryptosporidium parvum growth. Funkhouser-Jones LJ, Xu R, Wilke G, Fu Y, Shriefer LA, Makimaa H, Rodgers R, Kennedy EA, VanDussen KL, Stappenbeck TS, Baldridge MT, Sibley LD.bioRxiv. 2023 May 25:2023.05.25.542157. doi: 10.1101/2023.05.25.542157. Preprint.PMID: 37292732

Signaling & Metabolic Networks

A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution. Stuehr DJ, Biswas P, Dai Y, Ghosh A, Islam S, Jayaram DT. Bioessays. 2023 Jun 5:e2300055. doi: 10.1002/bies.202300055. PMID: 37276366

Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol-associated hepatitis.  Bellar A, Welch N, Dasarathy J, Attaway A, Musich R, Kumar A, Sekar J, Mishra S, Sandlers Y, Streem D, Nagy LE, Dasarathy S.Clin Transl Med. 2023 May;13(5):e1276. doi: 10.1002/ctm2.1276. PMID: 37228227

Mechanism of Tumor-Platelet Communications in Cancer. Dudiki T, Veleeparambil M, Zhevlakova I, Biswas S, Klein EA, Ford P, Podrez EA, Byzova TV. Circ Res. 2023 May 26;132(11):1447-1461. doi: 10.1161/CIRCRESAHA.122.321861. Epub 2023 May 5. PMID: 37144446

Transplant Immunology

Machine perfusion techniques for liver transplantation - A meta-analysis of the first seven randomized controlled trials. Parente A, Tirotta F, Pini A, Eden J, Dondossola D, Manzia TM, Dutkowski P, Schlegel A. J Hepatol. 2023 Jun 9:S0168-8278(23)00399-9. doi: 10.1016/j.jhep.2023.05.027. PMID: 37302578

Reply: Acute rejection in liver transplantation: Time for uniform definitions. Maspero M, Hashimoto K, Fairchild RL, Schlegel A. Hepatology. 2023 Jun 5. doi: 10.1097/HEP.0000000000000500. PMID: 37264696 No abstract available.

Left ventricular assist device mode: Co-pulse left ventricular unloading in a working mode of ex vivo heart perfusion. Sakota D, Kosaka R, Nagaoka E, Ohuchi K, Tahara T, Arai H, Sakanoue I, McCurry KR, Okamoto T. J Heart Lung Transplant. 2023 Jun;42(6):707-715. doi: 10.1016/j.healun.2023.01.009. Epub 2023 Feb 2. PMID: 36931988

Trends and Obstacles to Implement Dynamic Perfusion Concepts for Clinical Liver Transplantation: Results from a Global Web-Based Survey. Parente A, Flores Carvalho M, Panconesi R, Boteon YL, De Carlis R, Dutkowski P, Muiesan P, Dondossola D, Schlegel A. J Clin Med. 2023 May 30;12(11):3765. doi: 10.3390/jcm12113765. PMID: 37297960

Reply: Acute rejection after transplantation of machine perfused livers - We've barely scratched the surface. Maspero M, Hashimoto K, Fairchild RL, Schlegel A. Hepatology. 2023 May 26. doi: 10.1097/HEP.0000000000000483. Online ahead of print. PMID: 37226861 No abstract available.