We seek a Ph.D., M.D./Ph.D., or M.D. scientist with deep expertise in data science, advanced machine learning/AI, or bioinformatics methods and applications in multi-omics and multimodal data (eg. EHR, Imaging, wearables). This position addresses a critical departmental need to expand our computational and AI-driven research capabilities with applications to human health and disease. The ideal candidate must have a demonstrated record of independent research or a strong portfolio of team-science contributions, evidenced by impactful publications and extramural funding. The investigator will have opportunities to collaborate broadly across Cleveland Clinic Research, contribute to trainee mentorship, and leverage institutional strengths in omics, imaging, and clinical data science. A competitive start-up package and resources will be provided to support the candidate’s success.
Individuals will be appointed at Assistant, Associate, or Full Staff (equivalent to Assistant, Associate, or Full Professor, respectively) in the Department of Genomic Sciences and Systems Biology (GSSB), which is part of Cleveland Clinic Research, at Cleveland Clinic. For physician-scientists, joint appointments in clinical institutes will be made as appropriate. New recruits will join a highly collaborative environment within GSSB, with additional opportunities for collaboration and networking in the over 25 Departments and Centers in Cleveland Clinic Research.
Education:
• PhD or MD/PhD required
• MD with relevant laboratory experience may substitute for PhD
Salary Range: $148,000 to $380,000
The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate’s actual compensation will be determined after taking various factors into consideration such as the candidate’s work history, experience, skill set, and board certification. This is not inclusive of the value of Cleveland Clinic’s benefits package, which includes among other benefits, healthcare/dental/vision, and retirement.
Required Application Materials:
• Cover Letter
• CV
• Statement of research interests
All application materials should be submitted directly via email to the department at [email protected], and [email protected].
Contact:
Amy Petriella
About Cleveland Clinic Research
Cleveland Clinic has operated for over 100 years on the principle of bringing innovative teams together to advance care for patients. Today, we are a world leader in science-based healthcare. Our strategic plan for research harnesses information technology to power significant advances in both personalized and population medicine. A major component of our strategy includes our anchor role in building the Cleveland Innovation District. This unprecedented collaboration includes participation and investment by the State of Ohio along with five independent Cleveland healthcare and academic institutions and is designed to transform research, education and economic opportunities in Northeast Ohio, the United States, and across the world.
Cleveland Clinic’s research footprint spans one million square feet in Cleveland and Florida, with two new state-of-the-art facilities scheduled to open in 2025 and 2026. In 2024, research funding grew to $520 million — including $176 million in federal funding and 632 federal awards. In addition, Cleveland Clinic’s global footprint provides a wealth of resources to support research throughout the enterprise, including at our locations in Northeast Ohio, Florida, London and Abu Dhabi.
Cleveland Clinic’s global locations engage with a large, growing and diverse patient population, giving our research teams access to tens of thousands of unique biological samples through the centralized Cleveland Clinic BioRepository. Cleveland Clinic’s Discovery Accelerator partnership with IBM leverages high-performance computing using hybrid cloud, artificial intelligence (AI) and quantum computing technologies to empower and accelerate big data research, with more than 60 research projects in progress. The Center for Therapeutic Discovery provides full-scale drug discovery efforts to identify new drug targets and therapeutic compounds. All these efforts ultimately coordinate with Cleveland Clinic Innovations, the technology commercialization team serving to transform our discoveries into clinical practice.
Faculty in Cleveland Clinic Research typically also become members of the Molecular Medicine Graduate Training Program and other programs at the neighboring Case Western Reserve University School of Medicine, providing access to excellent PhD students and trainees.
About Cleveland Clinic
Cleveland Clinic’s vision is to become the best place for care and the best place to work in healthcare. We are committed to providing a safe, stable and financially fulfilling work environment. Cleveland Clinic is a nonprofit multispecialty international academic health system that is recognized in the United States and around the world for “Caring for life, researching for health and educating those who serve.”
Among Cleveland Clinic’s 83,000 employees worldwide are more than 5,786 salaried physicians and researchers, and 16,845 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. Cleveland Clinic is a 6,728-bed health system that includes a 173-acre main campus near downtown Cleveland, 23 hospitals, 280 outpatient facilities, including locations in northeast Ohio; Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2024, there were 15.7 million patient encounters, 332,991 hospital admissions and observations, and 319,935 surgeries and procedures throughout Cleveland Clinic’s health system.
Cleveland Clinic is pleased to be an equal employment/affirmative action employer. Smoke/drug free environment.
Amy Petriella
[email protected]
The Department of Quantitative Health Sciences (QHS) at the Cleveland Clinic seeks candidates for a doctoral-level faculty position at the Assistant or Associate level at the Cleveland, Ohio main campus. An academic faculty appointment at a rank commensurate with experience is available at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.
This is a full-time collaborative, hard-money position to work closely with clinician investigators in the Medical Specialties Institute (MSI), one of the 13 Cleveland Clinic Institutes. Applicants should possess methodological expertise in the design and analysis of clinical trials and observational studies that can be used to support research across multiple medical specialties within MSI. These specialties include the Departments of Allergy and Clinical Immunology, Rheumatology, Endocrinology, Genetics and Genomics, Kidney Medicine, and Dermatology. The position offers 30% protected time for independent creative scholarly work. The successful candidate will have support from a team of three Master-level statisticians (total of 2 FTE) who currently provide statistical analytic support across various aspects of MSI research. The candidate is expected to guide and mentor team members to provide more focused technical and collaborative support for MSI. Applicants must have a PhD or equivalent degree with a focus in biostatistics, applied statistics, and/or epidemiology.
The ideal candidate will thrive in a team science environment and appreciate learning about the diverse medical specialties that makeup MSI. They will collaborate on innovative study designs, apply creative analytical methods to tackle complex healthcare challenges, contribute to competitive grant proposals, and support the publication of research in academic, peer-reviewed journals. Exceptional written and verbal communication skills, along with the ability to effectively engage with investigators, are crucial. Recent graduates with some experience, as well as individuals with more advanced experience, are encouraged to apply. Rank and compensation will be commensurate with level of experience.
Medical Specialties Institute clinical investigators are physician scientists, who have over $10M in annual support from federal, state, foundation and industry sponsored sources. Ongoing investigator-initiated projects include clinical outcomes, epidemiology, use of large datasets to model chronic disease outcomes progression and management, development of AI-based predictive models for genetic kidney diagnosis, study of genetic risk factors for melanoma, integration of AI-driven alerts into EPIC to support precision medicine, and trials of CAR-T therapy and other novel treatment approaches for autoimmune disorders. Cleveland Clinic’s BioRepository provides the resources to integrate molecular phenotypes from biological samples with associated health information. The Institute is committed to growing its research portfolio and to developing the careers of medical students, residents, fellows, and junior faculty.
Cleveland Clinic Research includes a core group of 1,800+ dedicated research personnel and a broader network of physician scientists, investigators and shared resources across the health system. Estimated annual funding exceeds $520 Million and research operations take place all over the globe, including Northeast Ohio, Florida, Nevada, Canada, Abu Dhabi, London and beyond. In addition to state-of-the-art research facilities, the Clinic maintains high quality clinical registries, biorepositories, and a detailed electronic medical record database of more than 15 million annual patient encounters.
The Department of Quantitative Health Sciences has 23 faculty and over 132 members and is a multidisciplinary group of biostatisticians, epidemiologists, outcomes researchers, database developers and programmers that conducts translational medical research to improve patient care. Our teams collaborate with clinical investigators on translating clinical questions into testable research hypotheses, designing studies to address the clinical questions, and all aspects of data analysis (data-driven discovery, model building and validation, hypothesis testing, development of new statistical methods). Areas of disciplinary research application include biostatistical methods, clinical trials, population health, statistical genetics, bioinformatics, statistical computing, predictive modeling, and computational biology. For more career information see the Quantitative Health Sciences Career site.
Specific job requirements include:
Salary range of this position is 140K to 200K and reflects the anticipated range for new hires. A successful candidate's actual compensation will be determined after taking various factors into consideration, such as the candidate's work history, experience, and skill set. This salary range is not inclusive of the value of Cleveland Clinic's benefits package, which includes among other benefits, healthcare, dental, vision, and retirement. Please note that this is an on-site position.
The metropolitan and suburban areas of Cleveland comprise a population of over 3 million, rich in cultural resources and diversity. The city itself is centrally located to several other large cities and enjoys a low cost of living index. Cleveland and the surrounding area are home to several universities and colleges, fantastic parks, three major league professional sports teams, a lively performing arts scene, and a world-famous orchestra and art museum. Cleveland Clinic is among the world’s largest, busiest health centers, and a top-ranked U.S. hospital by U.S. News & World Report.
Interested candidates should email a curriculum vitae, the names of at least three references and a letter summarizing collaborative experience, research interests, and fit for the position to [email protected], Review of applications will begin immediately and continue until the position is filled.
Cleveland Clinic is pleased to be an equal employment opportunity employer and provide a smoke- and drug-free environment.
Stephanie Kocian
[email protected]
Cleveland Clinic Research
Cleveland Clinic Research invites applications for an Assistant Staff Scientist in Computational Biology with expertise in immunogenomics, neoantigens, and cancer immunotherapy response. This position will be part of a new department focused on cancer sciences, home to approximately 35 faculty with research programs spanning neuro-oncology, immuno-oncology, cell therapy, women’s cancers, and cancer pathophysiology Laboratories Immunotherapy & Precision Immuno-Oncology | Cleveland Clinic Research. The role will lead multiomic analyses (genomic, transcriptomic, proteomic, spatial transcriptomics) to elucidate tumor–immune interactions and biomarkers of response/toxicity on active and planned clinical trials. The successful candidate will serve as Director of the Translational and Correlative Sciences Program. The position requires complementary wet-lab skills to design, oversee, and troubleshoot translational and correlative studies, including sample processing, assay development/optimization, and QC. The hire will coordinate cross-functional project teams, integrate computational and experimental pipelines, and develop reproducible analytics.
Areas of particular interest and expertise include but are not limited to:
Computational Biology with expertise in immunogenomics, neoantigens, and cancer immunotherapy response.
Translational and correlative sciences
Qualifications
-PhD or MD/PhD in Computational Biology with additional substantive research training.
-A successful record or demonstrated interest in developing partnerships and collaborative relationships with other research laboratories.
-Experience leading teams.
-Excellent interpersonal skills, the ability to work independently, outstanding written and oral communication skills, and strong organizational skills.
-Experience developing and delivering bioinformatic workshops or educational activities is preferred
Essential Duties and Responsibilities
Major duties include:
-Direct high-quality research both independently and in collaboration with an interdisciplinary team of scientists and physicians within the department, Cleveland Clinic Research, and Cleveland Clinic’s clinical institutes
-Design and carry out original research in translational sciences.
-Develop research ideas into actionable research strategies and programs
-Publish research in peer-reviewed journals
Interested candidates should email their (1)curriculum vitae, (2) cover letter, and (3) research statement (3pages maximum) to [email protected] by January 31, 2025. Review of applications will occur on a rolling basis and continue until the position is filled.
Tiffany Masters
[email protected]
Assistant Professor – AI Assisted Drug Design
Center for Experimental Therapeutics
Cleveland Clinic
The Cleveland Clinic is establishing an innovative Center for Experimental Therapeutics whose vision is to be at the forefront of drug discovery and development. The Center is committed to pioneering new approaches that leverage cutting-edge technologies and accelerate the creation of novel therapeutics that address unmet medical needs. It is supported by the exceptional resources at the Cleveland Clinic.
We are seeking a highly motivated faculty member to join our dynamic team. The ideal candidate will have expertise in AI-based drug discovery (such as small molecules and biologics) and testing. This is a unique growth opportunity to join a top-ranked medical center and contribute to groundbreaking research at the intersection of artificial intelligence and therapeutic innovation.
Key Responsibilities:
· Develop and apply AI/ML models in multiple areas of therapeutic development including novel target identification as well as prediction and design of novel therapeutic biologics (such as antibodies and nanobodies) and/or small molecule compounds.
· Collaborate with interdisciplinary teams to integrate computational approaches with experimental validation.
· Secure research funding and lead projects in AI-driven drug discovery.
· Mentor graduate students and postdoctoral fellows, fostering a collaborative and innovative research environment.
· Publish high-impact research findings in peer-reviewed journals and present at scientific conferences.
Qualifications:
· Ph.D. and/or M.D.(or equivalent in Computational Biology, Bioinformatics, Computer Science, Chemistry, or a related field.
· Demonstrated expertise in AI and machine learning techniques (such as deep learning, generative AI, foundation models) as applied to drug discovery.
· Strong publication record showcasing innovative research in AI and therapeutics.
· Excellent communication and teamwork skills, with a commitment to interdisciplinary collaboration.
· Experience in securing research funding and leading research projects is desirable.
What We Offer:
· Access to state-of-the-art facilities and resources within a collaborative research environment at Cleveland Clinic.
· Opportunities for professional growth and development in a leading academic institution.
· Competitive salary and benefits package.
Cleveland Clinic
Cleveland Clinic has operated for over 100 years on the principle of bringing innovative teams together to advance patient care. Today, we are a world leader in science-based healthcare. Our strategic plan for research harnesses information technology to power significant advances in both personalized and population medicine. A major component of our strategy includes our anchor role in building the Cleveland Innovation District. This unprecedented collaboration includes participation and investment by the State of Ohio, along with five independent Cleveland healthcare and academic institutions and is designed to transform research, education, and economic opportunities in Northeast Ohio, the United States, and across the world.
Cleveland Clinic Research
Cleveland Clinic Research, a part of the global Cleveland Clinic enterprise, has a footprint spanning nearly 1 million square feet, with two new state-of-the-art facilities scheduled to open in 2026. In 2024, research funding grew to $520 million, which includes $176 million in federal funding across 632 federal awards. In addition, Cleveland Clinic’s global footprint provides a wealth of resources to support research throughout the enterprise, including our locations in Northeast Ohio, Florida, London, and Abu Dhabi.
Application Instructions:
Interested candidates should submit the following to Kelsey Garcia <[email protected]>:
· A cover letter detailing your research interests and career goals.
· A curriculum vitae (CV).
· A statement of research plans (2-3 pages).
· Contact information for three professional references.
Salary Range (Assistant Staff/Assistant Professor): $130,000 to $175,000
The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate’s actual compensation will be determined after taking various factors into consideration such as the candidate’s work history, experience, skill set, and board certification. This is not inclusive of the value of Cleveland Clinic’s benefits package, which includes among other benefits, healthcare/dental/vision, and retirement.
Cleveland Clinic is pleased to be an equal opportunity employer. Smoke/drug free environment.
Kelsey Garcia
[email protected]
The Center for Computational Life Sciences at Cleveland Clinic offers multiple faculty positions in contemporary AI/ML and/or quantum computational sciences for promising scientists to contribute to our biomedical research and healthcare system as innovative independent thought leaders.
Research areas of particular interest include analysis of multi-modal data including real-world data/electronic health records, genomics, and machine learning (including quantum machine learning). These faculty positions (rank commensurate with experience) will shape and expand contemporary AI/ML technologies or emerging quantum computing applications centered around biomedical science and healthcare, supported by strong institutional commitment. The Center for Computational Life Sciences serves as a multi-institutional hub for collaborative research in computational life sciences and biomedicine positioned at the intersection of biology, healthcare, computer science, quantum computing, predictive modeling, simulation, AI, and disruptive computing. Cleveland Clinic’s electronic health record (EHR) is one of the largest in the world, containing more than 20 years of data on over 7 million patients. The Lerner Research Institute conducts cutting-edge basic and translational research across the four impact areas of Cancer, Brain and Vision, Inflammation and Immunity, and Heart and Vascular diseases. With continuous streams of longitudinal, multi-modal, large volume clinical and research data (in-vitro, in-vivo, and pre-clinical), computational and data sciences at Cleveland Clinic are ripe for innovation. These positions will have dedicated access to Cleveland Clinic’s data and computing infrastructure supported by a strong research partnership with IBM. The first private sector, on-premises IBM Eagle Quantum System (127 Qubit) in the United States is located on Cleveland Clinic’s main campus. In the coming years, the first of IBM’s next-generation 1,000+ qubit quantum systems will follow.
These Faculty will join the Center for Computational Life Sciences programs that span artificial intelligence, quantum computing, and digital technologies that actively engage with universities, government, industry, start-ups and other relevant organizations globally and as part of Cleveland Clinic’s role in the Cleveland Innovation District. Cleveland Clinic launched many initiatives to enrich clinic and research data including the creation of an enterprise data vault as well as a clinical research data warehouse. Cleveland Clinic continuously works to improve the quality, governance, and democratization of its data to enhance and accelerate research. The program will elevate Cleveland Clinic as the leader for a new ecosystem for computational life sciences, focused on advancing computational biomedicine through the development and application of scalable tools and techniques fit for the transdisciplinary problems in biosciences. The Faculty’s research program will be located in the newly constructed state-of-the-art research space for the Center. Rank will be commensurate with experience (Assistant Staff and above); the most competitive applicants will be those who already have an established independent research program (e.g. 2-4 years).
The Cleveland Clinic offers a very generous seed package that includes salary support. The Faculty efforts are fully focused on research; teaching opportunities may be available for interested faculty within Cleveland Clinic Lerner College of Medicine, and graduate programs in partnering institutes.
Job Requirements
Essential Duties and Responsibilities
Major duties include:
Interested candidates should email a curriculum vitae, the names of at least three references and a letter summarizing experience, research interests, current funding sources (if applicable), and current team composition to [email protected]. Review of applications will occur on a rolling basis and continue until the positions are filled.
These positions are central and critical for the growth of computational biomedicine at the Cleveland Clinic.
Description of Cleveland Clinic Infrastructure for Health care Innovation
Cleveland Clinic has operated for over 100 years on the principle of bringing innovative teams together to provide better care for patients worldwide. Today, Cleveland Clinic is a world leader in science-based healthcare (see: Cleveland Clinic Main Campus Tour video). Our strategic plan for Research Development will harness information technology to power significant advances in both personalized and population medicine. A major component of the strategy will be our anchor role in building the Cleveland Innovation District. This unprecedented collaboration includes participation and investment by the State of Ohio along with 5 independent Cleveland healthcare and academic institutions and is designed to transform research, education, and economic opportunities in Northeast Ohio and globally.
As part of the Cleveland Innovation District, Cleveland Clinic has pledged to double its research footprint and output in the next five years and create thousands of new jobs. A substantial part of this commitment involves the creation of the Global Center for Pathogen & Human Health Research. A major goal of the center is to develop the means to prevent or combat the next pandemic or global health crisis and it will operate under the tandem principles of “Discover without Limits” and “Transform Discovery into Practice.”
The Global Center resides in 400,000 square feet of newly constructed research space housing state-of-the-art laboratories and technologies. Cleveland Clinic’s international clinical care footprint provides a large, growing, and varied patient population giving our research teams access to tens of thousands of unique biological samples through the centralized Cleveland Clinic BioRepository. Furthermore, the Discovery Accelerator, a newly established partnership with IBM Research, will leverage high- performance computing using hybrid cloud, artificial intelligence (AI), and quantum computing technologies to empower and accelerate big data research. The newly established Center for Therapeutic Discovery provides a full-scale drug discovery effort to identify new drug targets and therapies.
Annual Salary Range for this Position: $150,000.00 - 375,000.00 USD
The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate’s actual compensation will be determined after taking various factors into consideration such as the candidate’s work history, experience, skill set, and board certification. This is not inclusive of the value of Cleveland Clinic’s benefits package, which includes among other benefits, healthcare/dental/vision, and retirement.
We are a smoke/drug free environment.
Kathleen Babb
[email protected]
Job Description:
The Cleveland Clinic is searching for an Assistant, Associate or Full Professor-level faculty member to join its multidisciplinary Department of Genomic Medicine on the Cleveland Clinic Lerner Research Institute (LRI). We seek a M.D., M.D./Ph.D., or Ph.D. scientist or physician-scientist with strong research expertise in spatial omics/multi-omics (i.e., experimental or computational genomics/epigenomics and proteomics) of human diseases who can lead an independent research group. A track record of independent NIH or equivalent funding (for Associate or Full Professor-level) and a high impact publication track record is required. The investigator will have the opportunity to train PhD/MD students at the Cleveland Clinic Lerner College of Medicine (CCLCM) at the Case Western Research Institute (CWRU) and is expected to collaborate with other faculty members across 25+ departments/center at Cleveland Clinic main campus and other locations. Candidates will expect to purse novel research ideas and develop cutting-edge spatial omics research technologies in applying to multiple human disease and health-related fields. Wet lab space is available for those whose work requires it. Strong computational infrastructures from the LRI high-performance computing (HPC) clusters, quantum computer (The IBM Quantum System One), and the Cleveland Clinic Data Center will be available. A generous start up package and support will be provided to the candidate.
Individuals will be appointed at Assistant, Associate, or Full Staff (equivalent to Assistant, Associate, or Full Professor, respectively) in the Department of Genomic Medicine in the Lerner Research Institute at Cleveland Clinic. For physician-scientists, joint appointments in clinical institutes will be made as appropriate. New recruits will join a highly collaborative environments within Cleveland Clinic LRI, with additional opportunities for collaboration and networking in the over 25 Departments and Centers at the Lerner Research Institute. Cleveland Clinic provides outstanding opportunities for interactions with basic, translational, and clinical investigators from multiple specialties. Researchers have access of richer clinical biospecimens from the Cleveland Clinic BioRepository (CC-BioR) and the Cleveland Clinic Pathology & Laboratory Medicine across multiple clinical institutes, such as Taussig Cancer Center, Heart, Vascular & Thoracic Institute (Miller Family), Neurological Institute, Respiratory Institute, and many other clinical departments. We have world-class core facilities (including Imaging Core, Genomics Core and Genome Center) with the opportunity to grow them through the substantial expansion of the Lerner Research Institute and the formation of the Global Center for Pathogen Research and Human Health.
Cleveland Clinic Lerner Research Institute is an integrated research community consisting of 12+ Research Departments including genomic medicine, cardiovascular sciences, biomedical engineering, cancer biology, cell biology, immunology and inflammation, and neurosciences, and 10+ Centers of Research including cardiovascular research, anesthesiology research, cerebrovascular research, hematology and oncology molecular therapeutics, ophthalmic research, Alzheimer’s disease research, orthopedic research, structural biology, surgery research, thrombosis and vascular biology, and drug discovery and development (an annual budget of >$400 million). The mission of LRI is to understand the causes of human diseases and to develop new treatments and cures. The hallmark of LRI is its focus on disease-oriented research. This Institute fosters collaboration and interaction between clinicians, physician-scientists, and basic science researchers. More than 1,800 people (including approximately 200 principal investigators, over 250 postdoctoral fellows, and 100+ graduate students) work in ~200 labs conducting research projects focusing on cardiovascular, cancer, neurological, musculoskeletal, allergic and immunologic, eye, metabolic, and infectious disease.
Faculty typically also become members of the Molecular Medicine Graduate Training Program at our CCLCM and other programs at the neighboring Case Western Reserve University School of Medicine, providing access to excellent PhD/MD students and postdoctoral fellows. Cleveland Clinic LRI provides comprehensive career development and mentorship for junior faculty via our formalized coaching faculty and programs. Candidates should submit a cover letter, curriculum vitae, and statement of research interests by email to Amy Petriella ([email protected]) and Gili Ornan ([email protected])
Lab Research Topics:
• Spatial omic of human diseases
• Examples of Lab Research Topics include but are not limited to – single or multi-omics with or without imaging, single cell omics
• Faculty members are expected to have a research focus on omics of complex diseases and translational biology research.
Education:
• PhD or MD/PhD required
• MD with relevant laboratory experience may substitute for PhD
Required Application Materials:
• Cover Letter
• CV
• Statement of research interests
All application materials should be submitted directly via email to the department at [email protected], [email protected], and [email protected].
Annual Salary Range for this Position: $130,000.00 - 350,000.00 USD
The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate’s actual compensation will be determined after taking various factors into consideration such as the candidate’s work history, experience, skill set, and board certification. This is not inclusive of the value of Cleveland Clinic’s benefits package, which includes among other benefits, healthcare/dental/vision, and retirement.
Contact:
Amy Petriella
Amy Petriella
[email protected]
Learn more about Cleveland Clinic's culture, benefits and career development opportunities on the Cleveland Clinic jobs website.
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