Assistant Professor – AI Assisted Drug Design
Center for Experimental Therapeutics
Cleveland Clinic
The Cleveland Clinic is establishing an innovative Center for Experimental Therapeutics whose vision is to be at the forefront of drug discovery and development. The Center is committed to pioneering new approaches that leverage cutting-edge technologies and accelerate the creation of novel therapeutics that address unmet medical needs. It is supported by the exceptional resources at the Cleveland Clinic.
We are seeking a highly motivated faculty member to join our dynamic team. The ideal candidate will have expertise in AI-based drug discovery (such as small molecules and biologics) and testing. This is a unique growth opportunity to join a top-ranked medical center and contribute to groundbreaking research at the intersection of artificial intelligence and therapeutic innovation.
Key Responsibilities:
· Develop and apply AI/ML models in multiple areas of therapeutic development including novel target identification as well as prediction and design of novel therapeutic biologics (such as antibodies and nanobodies) and/or small molecule compounds.
· Collaborate with interdisciplinary teams to integrate computational approaches with experimental validation.
· Secure research funding and lead projects in AI-driven drug discovery.
· Mentor graduate students and postdoctoral fellows, fostering a collaborative and innovative research environment.
· Publish high-impact research findings in peer-reviewed journals and present at scientific conferences.
Qualifications:
· Ph.D. and/or M.D.(or equivalent in Computational Biology, Bioinformatics, Computer Science, Chemistry, or a related field.
· Demonstrated expertise in AI and machine learning techniques (such as deep learning, generative AI, foundation models) as applied to drug discovery.
· Strong publication record showcasing innovative research in AI and therapeutics.
· Excellent communication and teamwork skills, with a commitment to interdisciplinary collaboration.
· Experience in securing research funding and leading research projects is desirable.
What We Offer:
· Access to state-of-the-art facilities and resources within a collaborative research environment at Cleveland Clinic.
· Opportunities for professional growth and development in a leading academic institution.
· Competitive salary and benefits package.
Cleveland Clinic
Cleveland Clinic has operated for over 100 years on the principle of bringing innovative teams together to advance patient care. Today, we are a world leader in science-based healthcare. Our strategic plan for research harnesses information technology to power significant advances in both personalized and population medicine. A major component of our strategy includes our anchor role in building the Cleveland Innovation District. This unprecedented collaboration includes participation and investment by the State of Ohio, along with five independent Cleveland healthcare and academic institutions and is designed to transform research, education, and economic opportunities in Northeast Ohio, the United States, and across the world.
Cleveland Clinic Research
Cleveland Clinic Research, a part of the global Cleveland Clinic enterprise, has a footprint spanning nearly 1 million square feet, with two new state-of-the-art facilities scheduled to open in 2026. In 2024, research funding grew to $520 million, which includes $176 million in federal funding across 632 federal awards. In addition, Cleveland Clinic’s global footprint provides a wealth of resources to support research throughout the enterprise, including our locations in Northeast Ohio, Florida, London, and Abu Dhabi.
Application Instructions:
Interested candidates should submit the following to Kelsey Garcia <[email protected]>:
· A cover letter detailing your research interests and career goals.
· A curriculum vitae (CV).
· A statement of research plans (2-3 pages).
· Contact information for three professional references.
Salary Range (Assistant Staff/Assistant Professor): $130,000 to $175,000
The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate’s actual compensation will be determined after taking various factors into consideration such as the candidate’s work history, experience, skill set, and board certification. This is not inclusive of the value of Cleveland Clinic’s benefits package, which includes among other benefits, healthcare/dental/vision, and retirement.
Cleveland Clinic is pleased to be an equal opportunity employer. Smoke/drug free environment.
Kelsey Garcia
[email protected]
The Center for Computational Life Sciences at Cleveland Clinic offers multiple faculty positions in contemporary AI/ML and/or quantum computational sciences for promising scientists to contribute to our biomedical research and healthcare system as innovative independent thought leaders.
Research areas of particular interest include analysis of multi-modal data including real-world data/electronic health records, genomics, and machine learning (including quantum machine learning). These faculty positions (rank commensurate with experience) will shape and expand contemporary AI/ML technologies or emerging quantum computing applications centered around biomedical science and healthcare, supported by strong institutional commitment. The Center for Computational Life Sciences serves as a multi-institutional hub for collaborative research in computational life sciences and biomedicine positioned at the intersection of biology, healthcare, computer science, quantum computing, predictive modeling, simulation, AI, and disruptive computing. Cleveland Clinic’s electronic health record (EHR) is one of the largest in the world, containing more than 20 years of data on over 7 million patients. The Lerner Research Institute conducts cutting-edge basic and translational research across the four impact areas of Cancer, Brain and Vision, Inflammation and Immunity, and Heart and Vascular diseases. With continuous streams of longitudinal, multi-modal, large volume clinical and research data (in-vitro, in-vivo, and pre-clinical), computational and data sciences at Cleveland Clinic are ripe for innovation. These positions will have dedicated access to Cleveland Clinic’s data and computing infrastructure supported by a strong research partnership with IBM. The first private sector, on-premises IBM Eagle Quantum System (127 Qubit) in the United States is located on Cleveland Clinic’s main campus. In the coming years, the first of IBM’s next-generation 1,000+ qubit quantum systems will follow.
These Faculty will join the Center for Computational Life Sciences programs that span artificial intelligence, quantum computing, and digital technologies that actively engage with universities, government, industry, start-ups and other relevant organizations globally and as part of Cleveland Clinic’s role in the Cleveland Innovation District. Cleveland Clinic launched many initiatives to enrich clinic and research data including the creation of an enterprise data vault as well as a clinical research data warehouse. Cleveland Clinic continuously works to improve the quality, governance, and democratization of its data to enhance and accelerate research. The program will elevate Cleveland Clinic as the leader for a new ecosystem for computational life sciences, focused on advancing computational biomedicine through the development and application of scalable tools and techniques fit for the transdisciplinary problems in biosciences. The Faculty’s research program will be located in the newly constructed state-of-the-art research space for the Center. Rank will be commensurate with experience (Assistant Staff and above); the most competitive applicants will be those who already have an established independent research program (e.g. 2-4 years).
The Cleveland Clinic offers a very generous seed package that includes salary support. The Faculty efforts are fully focused on research; teaching opportunities may be available for interested faculty within Cleveland Clinic Lerner College of Medicine, and graduate programs in partnering institutes.
Job Requirements
Essential Duties and Responsibilities
Major duties include:
Interested candidates should email a curriculum vitae, the names of at least three references and a letter summarizing experience, research interests, current funding sources (if applicable), and current team composition to [email protected]. Review of applications will occur on a rolling basis and continue until the positions are filled.
These positions are central and critical for the growth of computational biomedicine at the Cleveland Clinic.
Description of Cleveland Clinic Infrastructure for Health care Innovation
Cleveland Clinic has operated for over 100 years on the principle of bringing innovative teams together to provide better care for patients worldwide. Today, Cleveland Clinic is a world leader in science-based healthcare (see: Cleveland Clinic Main Campus Tour video). Our strategic plan for Research Development will harness information technology to power significant advances in both personalized and population medicine. A major component of the strategy will be our anchor role in building the Cleveland Innovation District. This unprecedented collaboration includes participation and investment by the State of Ohio along with 5 independent Cleveland healthcare and academic institutions and is designed to transform research, education, and economic opportunities in Northeast Ohio and globally.
As part of the Cleveland Innovation District, Cleveland Clinic has pledged to double its research footprint and output in the next five years and create thousands of new jobs. A substantial part of this commitment involves the creation of the Global Center for Pathogen & Human Health Research. A major goal of the center is to develop the means to prevent or combat the next pandemic or global health crisis and it will operate under the tandem principles of “Discover without Limits” and “Transform Discovery into Practice.”
The Global Center resides in 400,000 square feet of newly constructed research space housing state-of-the-art laboratories and technologies. Cleveland Clinic’s international clinical care footprint provides a large, growing, and diverse patient population giving our research teams access to tens of thousands of unique biological samples through the centralized Cleveland Clinic BioRepository. Furthermore, the Discovery Accelerator, a newly established partnership with IBM Research, will leverage high- performance computing using hybrid cloud, artificial intelligence (AI), and quantum computing technologies to empower and accelerate big data research. The newly established Center for Therapeutic Discovery provides a full-scale drug discovery effort to identify new drug targets and therapies.
Annual Salary Range for this Position: $150,000.00 - 375,000.00 USD
The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate’s actual compensation will be determined after taking various factors into consideration such as the candidate’s work history, experience, skill set, and board certification. This is not inclusive of the value of Cleveland Clinic’s benefits package, which includes among other benefits, healthcare/dental/vision, and retirement.
We are a smoke/drug free environment.
Kathleen Babb
[email protected]
Job Description:
The Cleveland Clinic is searching for an Assistant, Associate or Full Professor-level faculty member to join its multidisciplinary Department of Genomic Medicine on the Cleveland Clinic Lerner Research Institute (LRI). We seek a M.D., M.D./Ph.D., or Ph.D. scientist or physician-scientist with strong research expertise in spatial omics/multi-omics (i.e., experimental or computational genomics/epigenomics and proteomics) of human diseases who can lead an independent research group. A track record of independent NIH or equivalent funding (for Associate or Full Professor-level) and a high impact publication track record is required. The investigator will have the opportunity to train PhD/MD students at the Cleveland Clinic Lerner College of Medicine (CCLCM) at the Case Western Research Institute (CWRU) and is expected to collaborate with other faculty members across 25+ departments/center at Cleveland Clinic main campus and other locations. Candidates will expect to purse novel research ideas and develop cutting-edge spatial omics research technologies in applying to multiple human disease and health-related fields. Wet lab space is available for those whose work requires it. Strong computational infrastructures from the LRI high-performance computing (HPC) clusters, quantum computer (The IBM Quantum System One), and the Cleveland Clinic Data Center will be available. A generous start up package and support will be provided to the candidate.
Individuals will be appointed at Assistant, Associate, or Full Staff (equivalent to Assistant, Associate, or Full Professor, respectively) in the Department of Genomic Medicine in the Lerner Research Institute at Cleveland Clinic. For physician-scientists, joint appointments in clinical institutes will be made as appropriate. New recruits will join a highly collaborative environments within Cleveland Clinic LRI, with additional opportunities for collaboration and networking in the over 25 Departments and Centers at the Lerner Research Institute. Cleveland Clinic provides outstanding opportunities for interactions with basic, translational, and clinical investigators from multiple specialties. Researchers have access of richer clinical biospecimens from the Cleveland Clinic BioRepository (CC-BioR) and the Cleveland Clinic Pathology & Laboratory Medicine across multiple clinical institutes, such as Taussig Cancer Center, Heart, Vascular & Thoracic Institute (Miller Family), Neurological Institute, Respiratory Institute, and many other clinical departments. We have world-class core facilities (including Imaging Core, Genomics Core and Genome Center) with the opportunity to grow them through the substantial expansion of the Lerner Research Institute and the formation of the Global Center for Pathogen Research and Human Health.
Cleveland Clinic Lerner Research Institute is an integrated research community consisting of 12+ Research Departments including genomic medicine, cardiovascular sciences, biomedical engineering, cancer biology, cell biology, immunology and inflammation, and neurosciences, and 10+ Centers of Research including cardiovascular research, anesthesiology research, cerebrovascular research, hematology and oncology molecular therapeutics, ophthalmic research, Alzheimer’s disease research, orthopedic research, structural biology, surgery research, thrombosis and vascular biology, and drug discovery and development (an annual budget of >$400 million). The mission of LRI is to understand the causes of human diseases and to develop new treatments and cures. The hallmark of LRI is its focus on disease-oriented research. This Institute fosters collaboration and interaction between clinicians, physician-scientists, and basic science researchers. More than 1,800 people (including approximately 200 principal investigators, over 250 postdoctoral fellows, and 100+ graduate students) work in ~200 labs conducting research projects focusing on cardiovascular, cancer, neurological, musculoskeletal, allergic and immunologic, eye, metabolic, and infectious disease.
Faculty typically also become members of the Molecular Medicine Graduate Training Program at our CCLCM and other programs at the neighboring Case Western Reserve University School of Medicine, providing access to excellent PhD/MD students and postdoctoral fellows. Cleveland Clinic LRI provides comprehensive career development and mentorship for junior faculty via our formalized coaching faculty and programs. Candidates should submit a cover letter, curriculum vitae, and statement of research interests by email to Amy Petriella ([email protected]) and Gili Ornan ([email protected])
Lab Research Topics:
• Spatial omic of human diseases
• Examples of Lab Research Topics include but are not limited to – single or multi-omics with or without imaging, single cell omics
• Faculty members are expected to have a research focus on omics of complex diseases and translational biology research.
Education:
• PhD or MD/PhD required
• MD with relevant laboratory experience may substitute for PhD
Required Application Materials:
• Cover Letter
• CV
• Statement of research interests
All application materials should be submitted directly via email to the department at [email protected], [email protected], and [email protected].
Annual Salary Range for this Position: $130,000.00 - 350,000.00 USD
The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate’s actual compensation will be determined after taking various factors into consideration such as the candidate’s work history, experience, skill set, and board certification. This is not inclusive of the value of Cleveland Clinic’s benefits package, which includes among other benefits, healthcare/dental/vision, and retirement.
Contact:
Amy Petriella
Amy Petriella
[email protected]
The Cleveland Clinic is searching for an Associate or Full Professor-level faculty member to join its multidisciplinary Department of Quantitative Health Sciences on the Cleveland Clinic main campus. This full-time faculty position offers a unique opportunity to contribute both collaboratively and independently with musculoskeletal researchers, spanning the range from basic and translational studies to sports medicine to orthopaedic surgery cohort studies and randomized trials, within a leading healthcare environment.
Position Overview
· Collaborative Research (70%): Design and analyze complex observational and experimental studies, including randomized clinical trials, in partnership with investigators from the Cleveland Clinic Department of Orthopaedic Surgery and Musculoskeletal Research Center.
· Independent Research (30%): Engage in independent research projects that advance the fields of biostatistics, epidemiology, data science, and their contributions to musculoskeletal research.
Key Responsibilities
· Collaborate with multidisciplinary teams of physicians, scientists, and engineers in musculoskeletal research.
· Lead and mentor a team of MS-level biostatisticians supporting musculoskeletal research.
· Develop and deploy data-intensive research studies, including the integration of diverse data sources (basic science, -omics, imaging, and patient-reported outcomes).
· Build data-driven models for patient phenotyping and outcome prediction using a wide range of modeling techniques, from classical statistical methods to artificial intelligence/machine learning and digital twinning.
Qualifications
· Education: Ph.D. in Statistics, Biostatistics, Epidemiology, or a related discipline.
· Experience: Demonstrated experience as a collaborative biostatistician in a clinical setting.
· Expertise:
- Clinical research design and statistical methodologies for cohort studies and clinical trials, including longitudinal data analysis, survival analysis, and modern statistical methods.
- Proficiency in machine learning, data mining, and advanced analytical methods for large-scale healthcare data.
- Experience with the integration and analysis of multi-source data is highly desirable.
· Leadership Skills: Strong leadership and collaborative abilities, with a desire to lead a biostatistical team.
· Communication Skills: Excellent written and oral communication skills in English. Enthusiasm for research in orthopaedic surgery, sports medicine, biomechanics, and related musculoskeletal research.
Appointment Details
· Funding: This is a hard-money faculty position with no explicit requirements to obtain additional external funding. However, a large portion of this individual’s effort will be in collaboration with musculoskeletal researchers to support extramurally funded programs, from which some external funding would be anticipated.
Salary range 140K to 200K. The pay range displayed on the job posting reflects the anticipated range for new hires. A successful candidate's actual compensation will be determined after taking various factors into consideration such as the candidate's work history, experience, skill set, and board certification. This is not inclusive of the value of Cleveland Clinic's benefits package, which includes among other benefits, healthcare/dental/vision, and retirement.
· Academic Affiliation: Non-tenured appointment at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, with rank commensurate with experience.
Interested candidates should email a curriculum vitae, the names of at least three references and a letter summarizing experience, research interests, and fit for the position to [email protected] Review of applications will begin immediately and continue until the position is filled.
Stephanie Kocian
[email protected]
Department of Quantitative Health Sciences is seeking a faculty Epidemiologist to lead collaborations with the Cleveland Clinic Integrated Hospital Institute, Department of Pulmonary Medicine to grow our emphasis in environmental epidemiology across the field of respiratory health. The ideal candidate will serve as a primary resource for existing research within the Cleveland Clinic System, while also engaging as an independent researcher to advance partnerships and collaborations with greater Northeast Ohio and improve the health of our community.
A doctoral degree is required. The position includes a non-tenured appointment to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University at rank commensurate with experience.
The ideal candidate would have a track record in environmental epidemiology research, with a skillset in modeling and exposure estimation of ambient or indoor air quality, and a rigorous grounding in spatial epidemiology techniques. Independent grant funding is not a requirement. A background in the impact of environmental exposures on respiratory health is preferred, though not required.
Job Requirements
Preferred qualifications and experience:
· PhD in environmental health sciences, epidemiology, or related field
· Experience with modeling and exposure estimation of ambient air quality
· Experience working with large datasets, including electronic medical record data
· Experience in spatial epidemiology and using GIS software such as ARcGIS
· Experience working in collaborative, multi-disciplinary research teams
This is a “hard money” position with the expectation of obtaining collaborative grant funding over time. A combination of collaborative and independent research is expected, with the majority of time dedicated to collaborative work. Salary range 140K to 200K. The pay range displayed on the job posting reflect the anticipated range for new hires. A successful candidate's actual compensation will be determined after taking various factors into consideration such as the candidate's work history, experince, skill set, and board certifiation. This is not inclusive of the value of Cleveland Clinic's benefits package, which includes among other benefits, healthcare/dental/vision, and retirement.
Interested candidates should email a curriculum vitae, the names of at least three references and a letter summarizing experience, research interests, and fit for the position to [email protected].
Review of applications will begin immediately and continue until the position is filled.
Stephanie Kocian
[email protected]
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