Cell Therapy & Immuno-Engineering Program
The Cell Therapy & Immuno-Engineering Program advances state-of-the-art cell engineering and T cell therapy developmental therapeutics, focusing on clinical development and research. We run cell therapy trials and develop new cell therapy approaches.
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The goal of the Melenhorst lab is to develop potent, safe T cell-based gene therapies for hematologic and solid organ malignancies.
Immunologic Medicine Division
The Immunologic Medicine Division is aimed at advancing translational immunology research. Our principal investigators and laboratories specialize in the areas of immuno-oncology, regenerative medicine, auto-immunity, developmental therapeutics, computational immunology and population immunology.
The Timothy Chan Lab investigates the genomic and immunologic drivers of tumor development and treatment response. We have a special interest in tumor immunology and immunotherapy development.
The Marcela Diaz lab studies the mechanisms that promote or inhibit anti-tumor immune responses and how they could be targeted with immunotherapies.
The Brian Gastman lab investigates tumor immunology and the novel inhibitory strategies that enhance current immunotherapeutic approaches, as well as cancer therapy resistance and oncogenes that will ultimately have clinical utility.
The Babal Kant Jha lab studies the functional basis of cancer-promoting genetic and epigenetic defects to help develop therapeutics.
The McGrail lab uses large-scale data to integrate system-level analyses with controlled experimental models in order to advance precision medicine in oncology and other diseases.
The Jacob Miller lab studies virally-associated neoplasms and develops molecular diagnostics for risk-adapted therapy and early cancer detection.
The Ni lab investigates alterations in metabolism-related genes and metabolites could have direct impact in cancer predisposition, tumor progression and immunotherapy treatment response.
The Anatoly Nikolaev lab investigates molecular and cellular pathways in tumor progression and resistance to chemo-radiation and immunotherapy in head and neck cancers.
The Gunnar Poplawski lab focuses on the development of regenerative and diagnostic strategies for neurodegenerative diseases.
The Natalie Silver lab is exploring novel ways to reprogram the tumor immune microenvironment to develop therapeutics for head and neck cancers.
The Jianjun Wu Lab focuses on understanding the fundamental mechanism of innate immunity and its impact on adaptive immunity, inflammation and cancer.
Precision Immuno-Oncology Program
The Precision Immuno-Oncology Program is comprised of faculty, scientists and shared resource platforms that establish enhanced discovery and translational capabilities at Cleveland Clinic and the Case Comprehensive Cancer Center. The Program offers enhanced clinical trial correlates for a wide range of basic and clinical areas of investigation.
Precision & Developmental Therapeutics Program
The Precision & Developmental Therapeutics Program collaborates with the Cleveland Clinic Cancer Center and Case Comprehensive Cancer Center to provide precision approaches, including immunogenomic profiling, and new immunotherapy trials to patients and investigators.