Clinical Trials
NIH (NINDS) — R01NS073717
Alberts, Jay
“The Cyclical Lower-Extremity Exercise (CYCLE) for Parkinson’s Trial”
NIH (NIAMS) — R01AR068342
Derwin, Kathleen / Iannotti, Joseph
“Failure with Continuity and its Relation to Rotator Cuff Repair Clinical Outcomes”
NIH (NIAMS) — R01AR077452
Li, Xiaojuan
“Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry”
NIH (NIAMS) — R01AR074131
Spindler, Kurt
“BEAR-MOON: A Two Arm Noninferiority Blinded Randomized Clinical Trial Comparing ACL Repair with BEAR Device vs. Standard of Care Autograft Patellar Tendon ACL Reconstruction”
NIH (NIAMS) — R01AR075422
Li, Xiaojuan
“Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI”
NIH (NICHD) — K01HD092556
Linder, Susan
“Cost-effectiveness and efficacy of a combined intervention to facilitate motor recovery following stroke”
NIH (NIAMS) — R21AR078401
Derwin, Kathleen
“Variation in Humeral Head Bone Marrow Characteristics and Their Associations with Rotator Cuff Repair Healing”
NIH (NIAMS) — R01AR055557 (sub-award)
Spindler, Kurt
“Partial Meniscectomy versus Nonoperative Management in Meniscal Tear with OA: An RCT”
NIH (NINDS) — U01NS113851 (sub-award)
Alberts, Jay
“Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3”
NIH (NIAMS) — U01AR080377 (sub-award)
Piuzzi, Nicolas
“HIP ATTACK-2 trial (HIP fracture Accelerated surgical care and TreaTment trACK) 2”
Grants
$10.4 Million
Total Grant Funding (2022)
Federal Grants
NIH (NCCIH) — R01AT011905
Marasco, Paul
“Sensing active movement of the self: reconsidering the cellular basis kinesthesia”
NIH (NIAMS) — R01AR073225
Streubel, Philipp
“3D bioprinting of biomimetic constructs for rotator cuff augmentation”
NIH (NIBIB) — R01EB025212
Erdemir, Ahmet
"Software for Practical Annotation and Exchange of Virtual Anatomy"
NIH (NIDCR) — R01DE029634
Muschler, George
"Understanding and Using Variation in Source Materials for MSC Fabrication"
NIH (NIAMS) — R01AR077452
Li, Xiaojuan
"Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry"
NIH (NIAMS) — R01AR075422
Li, Xiaojuan
"Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI"
NIH (NIAMS) — R01AR068342
Derwin, Kathleen / Iannotti, Joseph
"Failure with Continuity and its Relation to Rotator Cuff Repair Clinical Outcomes"
NIH (NINDS) — R01NS073717
Alberts, Jay
"CYClical Lower Extremity exercise for Parkinsons trial (CYCLE Trial)"
NIH (NIAMS) — R01AR074131
Spindler, Kurt
"BEAR-MOON: A Two Arm Noninferiority Blinded Randomized Clinical Trial Comparing ACL Repair with BEAR Device vs. Standard of Care Autograft Patellar Tendon ACL Reconstruction"
NIH (NIAMS) — R01AR075286
Ricchetti, Eric
"Identifying the Patient, Disease, Surgical, and Implant Positional Shift Factors that Predict Outcomes Following Total Shoulder Arthroplasty"
NIH (NIAMS) — R13AR076258
Spindler, Kurt
"Clinician Scholar Career Development Program (CSCDP)"
NIH (NIAMS) — R21AR078498
Apte, Suneel
“The proteolytic landscape of osteoarthritic cartilage”
NIH (NIAMS) — R21AR078401
Derwin, Kathleen
“Variation in Humeral Head Bone Marrow Characteristics and Their Associations with Rotator Cuff Repair Healing”
NIH (NINDS) — R21NS129147
Alberts, Jay
“The impact of exercise on subthalamic nucleus neural activity in Parkinson's disease”
NIH (NICHD) — K01HD092556
Linder, Susan
“Cost-effectiveness and efficacy of a combined intervention to facilitate motor recovery following stroke”
NIH (NIAMS) — K25AR078928
Yang, Mingrui
“Automated Arthroscopic Partial Meniscectomy Patient Outcome Prediction using Deep Learning”
NIH (NIAMS) — R01AR055557 (sub-award)
Spindler, Kurt
“Partial Meniscectomy vs. NonOperative Management in Meniscal Tear with OA: An RCT”
NIH (NIAMS) — U01AR080377 (sub-award)
Piuzzi, Nicolas
“HIP ATTACK-2 trial (HIP fracture Accelerated surgical care and TreaTment trACK) 2”
NIH (NINDS) — U01NS113851 (sub-award)
Alberts, Jay
"Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3"
Innovations
| 2015–2021 | 2022 | 2023 | 2024 | Cumulative | |
|---|---|---|---|---|---|
| Invention disclosures | 115 | 24 | 12 | 20 | 173 |
| Patent applications | 82 | 13 | 14 | 10 | 119 |
| Patents granted | 123 | 3 | 11 | 5 | 142 |
US PATENTS
Vijay Krishna, Sanjay Anand, Edward Maytin, Stephen Grobmyer: "Polyhydroxy fullerene sunscreen active agents and compositions". US Patent No: 11,957,769, granted Apr 2024.
Kathleen Derwin, Amit Aurora, Joseph P. Iannotti, Jesse A. McCarron: "Reinforced tissue graft". US Patent No: 11,951,232; granted Apr 2024.
Robert Assell, Andy Freeman, George Muschler: "Bone fragment and tissue processing system". US Patent No: 11,931,087; granted Mar 2024.
Jay L. Alberts, David D. Schindler, Jane Rhodes, Wendy Gabel, Jim Best: "Apparatus and related method to facilitate test via a computing device". US Patent No: 11,857,349; granted Jan 2024.
Muschler GF, Monnich JK, Kwee EJ, Powell KA, Herderick EE, Boehm CA, Adams TR, Germanoski R, Krakosh III F, Dunn J, Bantz D: "Systems and methods for detection, analysis, isolation and/or harvesting of biological objects". US Patent No: 11,579,160; granted Feb 2023.
McCrae K, Merkulov S, Alluri RK: "Human β2-glycoprotein I expression". US Patent No: 11,661,447; granted May 2023.
Colbrunn R, Nagle T, Gillespie C: "Hybrid control of a robotic system". US Patent No: 11,691,280; granted Jul 2023.
Iannotti JP, Barsoum WK, Bryan JA, O'Neill PD: "System and method for association of a guiding aid with a patient tissue". US Patent No: 11,730,497; granted Aug 2023.
Gillespie C, Colbrunn R, Nagle T: "Compliance correction in a robotic system". US Patent No: 11,745,341; granted Sep 2023.
Assell R, Freeman A, Muschler G: "Bone void filler preparation system". US Patent No: 11,850,326; granted Dec 2023.
Assell R, Freeman A, Muschler GF: "Bone fragment and tissue harvesting system". US Patent No: 11,337,710; granted May 2022.
Baker JJ, Gingras PH, Priest R, Derwin K, Iannotti JP, Sahoo S, Baker AR: "Radiopaque tissue marker". US Patent No: 11,413,112; granted Aug 2022.
Schoenhagen P, Chen PH, Piraino D, Obuchowski N: "Automated identification of acute aortic syndromes in computed tomography images". US Patent No: 11,475,561; granted Oct 2022.
Assell R, Freeman A, Muschler G: "Bone void filler preparation system". US Patent No: 10,953,134; granted Mar 2021.
Iannotti JP, Barsoum WK, Bryan JA, O'Neill PD: "System of preoperative planning and provision of patient-specific surgical aids". US Patent No: 10,973,535; granted Apr 2021.
Derwin KA, Iannotti JP, Sahoo S: "Reinforced tissue graft". US Patent No: 11,013,590; granted May 2021.
Muschler GF, Monnich JK, Kwee EJ, Powell KA, Herderick EE, Boehm CA, Adams TR, Germanoski R, Krakosh III F, Dunn J, Bantz D: "Systems and methods for detection, analysis, isolation and/or harvesting of biological objects". US Patent No: 10,564,172; granted Feb 2020.
Schindler DD, Alberts JL, Hirsch JR: "Systems and Methods to Assess Balance and Stability". US Patent No: 10,588,546; granted Mar 2020.
Iannotti JP, Barsoum WK, Bryan JA, O'Neill PD: "System and Method for Association of a Guiding Aid with a Patient Tissue". US Patent No: 10,624,655; granted Apr 2020.
Assell R, Freeman A, Muschler GF: "Bone Fragment and Tissue Harvesting System". US Patent No: 10,610,242; granted Apr 2020.
Alberts JL, Bermel R, Rao S, Schlinder DD: "Assessment of Low Contrast Visual Sensitivity". US Patent No: 10,667,682; granted Jun 2020.
Alberts JL, McIntyre C: "System and Method for Motor and Cognitive Analysis". US Patent No: 10,741,287; granted Aug 2020.
Derwin K, Aurora A, Iannotti JP, McCarron, JA: "Reinforced Tissue Graft". US Patent No: 10,758,644; granted Sep 2020.
Cheng J: "Devices and Methods for Treating Medical Conditions Associated with Sacroiliac Joint Abnormalities". US Patent No: 10,849,708; granted Dec 2020.
Alberts JL, Schindler DD: "Object Recognition by Touch Screen". US Patent No: 10,206,609; granted Feb 2019.
Iannotti JP, Barsoum WK, Bryan JA: "System and Method for Assisting with Attachment of a Stock Implant to a Patient Tissue". US Patent No: 10,258,352; granted Apr 2019.
Iannotti JP, Barsoum WK, Bryan JA: "Apparatus and Method for Providing a Reference Indication to a Patient Tissue". US Patent No: 10,307,174; granted Jun 2019.
Assell R, Freeman A, Muschler G: "Bone Fragment and Tissue Processing System". US Patent No: 10,342,552; granted Jul 2019.
Derwin KA, Iannotti JP, Milks RA: "Devices and Methods for Tissue Graft Delivery". US Patent No: 10,383,657; granted Aug 2019.
Alberts JL, Schindler DD, Rhodes J, Gabel W, Best J: "Apparatus and Related Method to Facilitate Testing Via a Computing Device". US Patent No: 10,420,497; granted Sep 2019.
Iannotti JP, Barsoum WK, Bryan JA, O'Neill P: "Alignment of Manipulable Sensor Assembly". US Patent No: 10,456,062; granted Oct 2019.
Assell R, Freeman A, Muschler G: "Bone Void Filler Preparation System". US Patent No: 10,456,502; granted Oct 2019.
Alberts JL, Rudick RA, Schindler DD, Hirsch J, Rao SM, Bethoux F, Linder S, Miller D: "Performance Test for Evaluation of Neurological Function". US Patent No: 10,470,679; granted Nov 2019.
Iannotti JP, Barsoum WK, Bryan JA: "System and Method for Assisting with Arrangement of a Stock Instrument with Respect to a Patient Tissue". US Patent No: 10,512,496; granted Dec 2019.
Alberts JL, Bermel R, Rao S, Schindler DD: "Assessment of Low Contrast Visual Sensitivity". US Patent No: 10,028,653; granted Jul 2018.
Derwin KA, Calabro A: "Biocompatible Tissue Graft". US Patent No: 10,004,586; granted Jun 2018.
Evans PJ, Trickett J: "Multipurpose Membranes, Methods for Forming, and Applications Thereof". US Patent No: 10,086,110; granted Oct 2018.
Iannotti JP, Barsoum WK, Bryan JA: "System and Method for Assisting with Attachment of a Stock Implant to a Patient Tissue". US Patent No: 9,877,735; granted Jan 2018.
Machado AG, Alberts JL, McIntyre C, Schindler DD: "Evaluation of Movement Disorders". US Patent No: 10,028,695; granted Jul 2018.
Alberts JL: "System and Method to Facilitate Analysis of Brain Injuries and Disorders". US Patent No: 9,610,029; granted Apr 2017.
Alberts JL, McIntyre CC: "Reversing Cognitive-Motor Impairments in Patients Having a Neuro-Degenerative Disease Using a Computational Modeling Approach to Deep Brain Stimulation Programming". US Patent No: 9,776,003; granted Oct 2017.
Alberts JL, McIntyre CC: "System and Method for Motor and Cognitive Analysis". US Patent No: 9,653,002; granted May 2017.
Alberts JL, Schindler DD: "Object Recognition by Touch Screen". US Patent No: 9,737,242; granted Aug 2017.
Iannotti JP: "Prosthetic Articulation Surface Mounting". US Patent No: 9,572,670; granted Feb 2017.
Iannotti JP, Barsoum WK, Bryan JA, O'Neill PD: "System of Preoperative Planning and Provision of Patient-Specific Surgical Aids". US Patent No: 9,741,263; granted Aug 2017.
Iannotti JP, Barsoum WK, Bryan JA, O'Neill PD: "System of Preoperative Planning and Provision of Patient-Specific Surgical Aids". US Patent No: 9,717,508; granted Aug 2017.
Iannotti JP, Barsoum WK, Bryan JA, O'Neill PD: "System and Method for Association of a Guiding Aid with a Patient Tissue". US Patent No: 9,615,840; granted Apr 2017.
Polster JM, Hoffman G: "Tissue Sampling Device". US Patent No: 9,622,727; granted Apr 2017.
Derwin KA, Iannotti JP, Milks RA: "Devices and Methods for Tissue Graft Delivery". US Patent No: 9,265,524; granted Feb 2016.
Iannotti JP: "Humeral Joint Replacement Component". US Patent No: 9,512,445; granted Dec 2016.
Iannotti JP: "Prosthetic Articulation Surface Mounting". US Patent No: 9,241,804; granted Jan 2016.
Iannotti JP, Barsoum WK, Bryan JA: "Apparatus and Method for Providing a Reference Indication to a Patient Tissue". US Patent No: 9,326,781; granted May 2016.
Iannotti JP, Barsoum WK, Bryan JA: "System and Method for Assisting with Arrangement of a Stock Instrument with Respect to a Patient Tissue". US Patent No: 9,254,155; granted Feb 2016.
Iannotti JP, Bonutti PM: "Methods and Devices for Bone Preparation". US Patent No: 9,439,704; granted Sep 2016.
Iannotti JP, Williams G, Koka D, Hollis MC: "Glenoid Vault Fixation". US Patent No: 9,439,768; granted Sep 2016.
Iannotti J, Williams G, Koka D, Hollis MC: "Shoulder Arthroplasty". US Patent No: 9,414,927; granted Aug 2016.
Miniaci A, Fening SD, Hartzell BE: "Apparatus and Method for Sequentially Anchoring Multiple Graft Ligaments in a Bone Tunnel". US Patent No: 9,339,370; granted May 2016.
Polster J: "Percutaneous Needle Guide and Method". US Patent No: 9,381,035; granted Jul 2016.
Polster JM: "Method and Apparatus for Tissue Sampling". US Patent No: 9,326,754; granted May 2016.
Alberts JL: "Systems and Methods for Improving Motor Function with Assisted Exercise". US Patent No: 9,067,098; granted Jun 2015.
Fening SD, Miniaci A: "Apparatus and Method for Sequentially Anchoring Multiple Graft Ligaments in a Bone Tunnel". US Patent No: 9,011,536; granted Apr 2015.
Iannotti JP, Barsoum WK, Bryan JA: "Apparatus and Method for Dictating at Least One of a Desired Location and a Desired Trajectory for Association of a Landmark with a Patient Tissue". US Patent No: 9,198,732; granted Dec 2015.
Iannotti JP, Barsoum WK, Bryan JA: "Directed Structure Placement Guide". US Patent No: 9,033,990; granted May 2015.
Iannotti JP, Barsoum WK, Bryan JA: "Positioning Apparatus and Method for a Prosthetic Implant". US Patent No: 9,011,452; granted Apr 2015.
Iannotti JP, Barsoum WK, Bryan JA: "Apparatus and Method for Providing a Reference Indication to a Patient Tissue". US Patent No: 8,992,539; granted Mar 2015.
Iannotti JP, Barsoum WK, Bryan JA: "Apparatus and Method for Transferring Predetermined Spatial Positioning Information to an Adjustable Tool". US Patent No: 8,926,627; granted Jan 2015.
Iannotti JP, Bonutti PM: "Methods and Devices for Bone Preparation". US Patent No: 9,216,046; granted Dec 2015.
Machado A, Alberts JL, McIntyre C, Schindler D: "Evaluation of Movement Disorders". US Patent No: 9,186,095; granted Nov 2015.
Muschler G, Caralla T, Hascall V, Midura R: "Enrichment of Tissue-Derived Adult Stem Cells Based on Retained Extracellular Matrix Material". US Patent No: 9,045,735; granted Jun 2015.
Polster JM: "Augmented Reconstruction for Computed Tomography". US Patent No: 9,153,045; granted Oct 2015.
Pilot Project Programs
The Musculoskeletal Research Center's Pilot Project Program for Cleveland Clinic investigators is available to support currently unfunded, novel, particularly innovative, disease-oriented projects that are in need of the early data that would make them competitive for extramural funding. Funding will be available to support projects along the entire continuum of biomedical investigation, including discovery, translation and direct patient-involved research.
Two types of awards of up to $25,000 each are available: (1) MSRC General awards are for musculoskeletal research projects on any topic related to musculoskeletal research, and (2) MSRC MSK Imaging awards are for musculoskeletal imaging research projects. Announcement of funding opportunity will be made to MSRC members via email.
InfoReady Review is used to manage Pilot Project submissions. Each competition will be launched on the InfoReady Review home page one month prior to the deadline. If you have any issues submitting an application, please contact us.
General Funded Projects
- Suneel Apte, MBBS, DPhil: "Synovial fluid degradomics for discovery of proteolytic pathways and biomarkers in juvenile idiopathic arthritis" (September 2023)
- Sambit Sahoo, MD, PhD: "Characterizing patient reported outcome measures (PROMs) following RCR" (September 2023)
- Anabelle Visperas, PhD: “In Depth Proteomic and Transcriptomic Analysis of Periprosthetic Joint Infection.” (September 2022)
- Megan Jack, MD, PhD: “The Role of Exercise on Macrophage Polarization at the Neuromuscular Junction Following Peripheral Nerve Injury.” (September 2022)
- Unnikrishnan Chandrasekharan, PhD: "Protein arginine methyltransferase 5 (PRMT5), a novel drug target of inflammatory arthritis and cardiovascular comorbidity." (March 2021)
- Jillian Beveridge, PhD: "Computational Modeling of In Vivo ACL Function" (September 2020)
- Suneel Apte, MBBS, DPhil: "Proteome-wide analysis of cartilage degradation in knee OA" (March 2020)
- Carlos Higuera-Rueda, MD: "Efficacy of MagDAA gel on disruption of established bacterial biofilm in a rabbit model of periprosthetic joint infection (PJI)" (March 2019)
MSK Imaging Funded Projects
- Lauren Wichman, MD: "Does Energy Deficiency Contribute to Knee Injuries in Female Athletes? (March 2025)"
- D. Patrick Corrigan, PhD: "Identifying muscle characteristics related to impaired physical function and altered walking biomechanics in adults with knee osteoarthritis" (March 2025)
- Kihwan Kim: "Investigation of the effect of semaglutide treatment on muscle metabolic function using phosporus-31 magnetic resonances spectroscopy" (November 2024)
- Aaron Lear, MD: “Identifying Factors Contributing to Cartilage Degradation for Adolescents with Patellofemoral Pain.” (September 2022)
- Saeid Mirzai, DO: “Secondary Sarcopenia from Heart Failure: The Value of Imaging Modalities for its Diagnosis and Rehabilitation for its Management.” (September 2022)
- Stefan Zbyn, PhD: “Characterization of Cartilage and Meniscus Degeneration by Morphological and Quantitative Magnetic Resonance Imaging with Ultra-high Spatial Resolution at 7 Tesla.” (September 2022)
- Sibaji Gaj, PhD: "Novel automated lesion segmentation in post-traumatic osteoarthritis using unsupervised deep-learning methods" (March 2022)
- Bong-Jae Jun, PhD: "Characterization of Post-Traumatic Osteoarthritis (PTOA) Following anterior cruciate ligament reconstruction (ACLR) using cone-beam computed tomography (CBCT) imaging" (September 2021)
- Ceylan Colak, MD and Richard Lartey, PhD: "Optimizing Non-Contrast Magnetic Resonance Imaging (MRI) Sequences for Knee Synovitis" (Junior Investigator, September 2020)
- Maryam Zokaeinikoo, PhD: "Automated knee radiograph analysis using deep-learning techniques" (Junior Investigator, September 2020)
- Brendan Eck, PhD: "Characterization of sarcopenia by magnetic resonance fingerprinting and phosphorous magnetic resonance spectroscopic imaging" (Junior Investigator, September 2019)
- Jinjin Ma, PhD: "Investigating MR Biomarkers of Bone Marrow Quality in Musculoskeletal Disease" (Junior Investigator, September 2018)
- Mingrui Yang, PhD: "Automated Arthroscopic Partial Meniscectomy Patient Outcome Prediction using Deep Learning" (Junior Investigator, September 2018)
- Nicholas Piuzzi, MD: "A Comparative and Correlative Evaluation of Early to Late Stage Osteoarthritis in Human Knee Cartilage utilizing Clinical and Preclinical MRI Imaging (3T & 7T) with Histopathology and Immunohistochemistry as the Standard" (Junior Investigator, March 2018)
- John Elias, PhD: "Optimizing Surgical Stabilization for Patellar Instability to Reduce the Risk of Arthritis" (Established Investigator, March 2018)
Other Resources
- Program for Advanced Musculoskeletal Imaging (PAMI)
- Lerner Research Institute Research Core Services
- Clinical Research Unit (CRU)
- Cleveland Clinic Innovations (CCI)
- Amy & David Krohn Family Orthopaedic Outcomes Center
Members
MSRC Steering Committee
- Suneel Apte, DPhil,
Biomedical Engineering - Ahmet Erdemir, PhD,
Biomedical Engineering - M Elaine Husni, MD, MPH,
Rheumatic and Immunologic Disease - Xiaojuan Li, PhD,
Biomedical Engineering
- Eric Ricchetti, MD,
Orthopaedic Surgery - Kurt Spindler, MD,
Orthopaedic Surgery - Carl S. Winalski, MD,
Diagnostic Radiology
Lerner Research Institute
- Biomedical Engineering
-
Cancer Biology
- Cardiovascular & Metabolic Sciences
- Department of Research (Akron General)
-
Immunotherapy & Precision Immuno-Oncology
- Infection Biology
- Quantitative Health Sciences
-
Research Core Services
Surgical Specialty
-
Orthopaedic Surgery
- Damien Billow, MD
- Michael Bloomfield, MD
- Georgeanne Botek, DPM
- Zachary Burke, MD
- Sagar Chawla, MD
- Matthew Deren, MD
- Vahid Entezari, MD
- Lutul Farrow, MD
- Jason Genin, DO
- Ryan Goodwin, MD
- Jason Ho, MD
- Matthew Kampert, DO
- Dominic King, DO
- Steven Maschke, MD
- Nate Mesko, MD
- Robert Molloy, MD
- George Muschler, MD
- Lukas Nystrom, MD
- Nicolas Piuzzi, MD
- Eric Ricchetti, MD
- Sami Rifat, MD
- Paul Saluan, MD
- Jonathan Schaffer, MD, MBA
- Mark Schickendantz, MD
- Kurt Spindler, MD
- Yirka Vacca, PA-C
- Heather Vallier, MD
- Orthopaedic Surgery (Akron General)
- Orthopaedic Surgery (Florida)
- Rehabilitation and Sports Therapy
Diagnostic Services
- Diagnostic Radiology
- Nuclear Medicine
- Pathology
Medical Specialty
- Rheumatology and Immunologic Diseases
Neurosciences
- Center for Spine Health
- Neurology
- Neurosurgery
- Neurosurgery (Florida)
- Physical Medicine and Rehabilitation
Children's Services
- Center for Pediatric Rheumatology and Immunology
- General Pediatrics
Hospital Based Care
- Department of Pain Management
- Pulmonary Medicine
Digestive Disease
- Colorectral Surgery
- Gastroenterology & Hepatology