Featured Faculty

Please view the featured faculty that have served as Molecular Medicine advisors.

Biomedical Engineering

Suneel S. Apte, MBBS, DPhil

Research Interests:

extracellular matrix; metalloproteinases; adamts proteases; adamts-like proteins; morphogenesis; cardiovascular biology; birth defects; fetal-maternal biology; eye disorders; neural tube; craniofacial development; smooth muscle; musculoskeletal biology; post-translational modification; inherited connective tissue disorders;osteoarthritis; proteomics

Jan Jensen, PhD

Research Interests:

diabetes; pancreas development; insulin-producing cells; stem cell therapy

Vinod Labhasetwar, PhD

Research Interests:

nanomedicine; nanoparticles; cancer; imaging; targeted drug delivery; stroke; antioxidant delivery

Cancer Biology

Alexandru Almasan, PhD

Research Interests:

autophagy; apoptosis; cell cycle; dna damage; dna repair; cancer therapeutics; radiation therapy; leukemia; epithelial tumors; prostate cancer

Brian P. Rubin, MD, PhD

Research Interests:

sarcoma; genetics, oncogene addiction, targeted therapy, pathology, mouse models of human cancer

Nima Sharifi, MD

Research Interests:

prostate cancer; androgens; metabolism; steroids; castration-resistant prostate cancer; androgen receptor; hormone therapy; medical oncology; dihydrotestosterone; enzymes; biochemistry

George R. Stark, PhD

Research Interests:

interferons; IL-6; NFkB; STAT3; EGFR; drug resistance; DNA repair; lung cancer; breast cancer; prostate cancer; glioblastoma; septic shock

Emina Huang, MD

Research Interests:

colorectal cancer; inflammation; colitis; cancer stem cells; organoids; microenvironment

Cardiovascular $ Metabolic Sciences

Jonathan Mark Brown, PhD

Research Interests:

lipid metabolism; lipoprotein metabolism; atherosclerosis; obesity; diabetes; reverse cholesterol transport; triacylglycerol; nutrition

Jan Claesen, PhD

Research Interests:

intestinal and skin microbiome; bacterial genetics; synthetic biology; biosynthetic gene clusters; biochemistry; molecular mechanisms

Donna M. Driscoll, PhD

Research Interests:

RNA biology; mRNA translational control; nutritional regulation of gene expression; selenium

Paul L. Fox, PhD

Research Interests:

angiogenesis; atherosclerosis; cell migration; endothelial cells; iron metabolism; macrophages; translational control

Stanley L. Hazen, MD, PhD

Research Interests:

inflammation; atherosclerosis; asthma; myeloperoxidase; cardiovascular diseases; HDL; peroxidases; airway remodeling; intestinal microbiota; gut flora; cardiometabolic disease

Justin Lathia, PhD

Research Interests:

cancer stem cells; brain tumors; cell to cell communication; in vivo imaging

Richard A. Padgett, PhD

Research Interests:

transcription; RNA processing; RNA splicing; splicing factors; relation to cancer and developmental diseases; gene structure and function; genomics; evolution of genomes; RNA biochemistry

Jonathan D. Smith, PhD

Research Interests:

Atherosclerosis; HDL metabolism; Atrial fibrillation; Genetics; Genomics; eQTL; Gene expression; Reverse cholesterol transport; Dysfunctional HDL; RNAseq; Allelic expression imbalance; ABCA1; Mouse models; Zinc finger nuclease

Sathyamangla Venkata Naga Prasad, PhD

Research Interests:

Beta-adrenergic Receptor Resensitization; Non-canonical PI3K Signaling; Cardiac Hypertrophy and Heart Failure; MicroRNAs in Heart Failure and Cardiac Remodeling.

Olga Stenina Adognravi, PhD

Research Interests:

Diabetes; Vascular Complications; Hyperglycemia; Angiogenesis; Atherosclerosis; Gene Regulation; Transcription; Translation; MicroRNA; Extracellular Matrix; Thrombospondin

David Van Wagoner, PhD

Research Interests:

Atrial Fibrillation; Arrhythmia Mechanisms; Calcium Channels; Cellular Electrophysiology; Fibrosis; Genetics of Cardiovascular Disease; Inflammatory Mechanisms of Cardiovascular Disease; Ion Channel Biology; Patch Clamp; Potassium Channels; Nitric Oxide Regulation; S-nitrosylation; Stroke

Sarah Schumacher-Bass, PhD

Research Interests:

G Protein-coupled Receptors (GPCRs); Structure-Function of GPCR Kinase 2 (GRK2) Peptides; Proteomics; Cardiac Signaling and Metabolism; Cardiovascular Remodeling, Cardiac Hypertrophy; Ischemia; Heart Failure

Genomic Medicine

Charis Eng, MD, PhD

Research Interests:

Cancer Genetics; Cancer Genomic Medicine; Cancer Research; Cancer Family History; Cancer Predisposition; Cancer Susceptibility; Heritable Cancer Syndromes; Cowden syndrome; Integrative Genomics; Cancer Metagenomics; Microbiome; Metabolome; Breast Cancer; Thyroid Cancer; Endocrine Cancer; Pheochromocytoma; Autism Research; PTEN; SDHA; SDHB; SDHC; SDHD; KLLN; KILLIN

Angela H. Ting, PhD

Research Interests:

Cancer; Epigenetics; DNA Methylation; Prostate Cancer; Colon Cancer; Genomics; High Throughput Sequencing

Bin Zhang, PhD

Research Interests:

Mechanism of Intracellular Trafficking in Human Disease Development; Protein Secretion; Endoplasmic Reticulum Stress; Cargo Receptors; Cardiovascular Diseases; Cancer.

Dennis Lal, PhD

Research Interests:

Copy Number Variants; Epilepsy; Missense Variant Mutation; Neurodevelopmental Disorders

Ignacio Mata, PhD

Research Interests:

Neurology; Population Genetics; Genomics; Neurodegeneration; Parkinson's Disease; Precision Medicine, Latinos

Inflammation and Immunity

Mark A. Aronica, MD

Research Interests:

asthma, extracellular matrix

William M. Baldwin, MD, PhD

Research Interests:

cardiac and renal allograft rejection, vascular inflammation

Carol de la Motte, PhD

Research Interests:

Inflammatory bowel disease; inflammation; leukocyte adhesion; platelet hyaluronidase; Human milk glycans; hyaluronan; intestinal protection; beta defensins; Salmonella infection

Serpil C. Erzurum, MD

Research Interests:

asthma; pulmonary vascular disease; hypoxia; metabolism

Robert L. Fairchild, PhD

Research Interests:

Skin disease, Skin and cardiac allograft rejection, T cell recruitment to inflammation in peripheral tissues

Trine N. Jorgensen, PhD

Research Interests:

Autoimmunity; Systemic lupus erythematosus; The role of type I interferon in autoimmunity; Gender differences

Xiaoxia Li, PhD

Research Interests:

TSignal transduction in innate and adaptive immunity

Feng Lin, PhD

Research Interests:

Complement ; Innate immunity; Autoimmune diseases; transplant rejection; Stem cells; multiple sclerosis, myasthenia gravis, posterior uveitis

Christine McDonald, PhD

Research Interests:

Inflammatory Bowel Disease; Crohn's disease; Anti-Bacterial Defenses; Skin Infection; NOD2; Innate Immunity; Autoinflammatory Disease; Antibiotic-Resistant Bacteria; Diet; Microbes; Genetics

Laura Nagy, PhD

Research Interests:

alcoholic liver disease; macrophages; C1q; apoptosis; fibrosis; liver disease; alcohol; Heme-oxygenase-1; inflammation; necroptosis; high-fat diet; liver injury; fatty liver disease; complement; hepatocytes; alcoholic hepatitis; hepatic stellate cell; adiponectin; MIF; carbon tetrachloride

Anna Valujskikh, PhD

Research Interests:

Immunologic memory; memory T-cells; allograft rejection; transplantation; therapies for transplant recipients

Michelle Longworth, PhD

Research Interests:

Condensins; CAP-D3; genome organization; transcription; genome stability; enteric infection; inflammatory bowel disease; innate immune response

Neurosciences

Bruce Trapp, PhD

Research Interests:

multiple sclerosis; glia; oligodendrocytes; astrocytes; neuroprotection; myelin; autism

Tara DeSilva, PhD

Research Interests:

neuroscience; neuroimmunology; demyelination diseases; transverse myelitis; multiple sclerosis; neurodegeneration; autoimmunity; neuron-glia interactions; oligodendrocyte biology; neurovascular unit; blood-brain barrier; animal models of autoimmune demyelination

Antoine Louveau, PhD

Research Interests:

neuroimmunology; meninges; vasculature; lymphatic; tissue signaling; development; autism; neurodegeneration

Ophthalmic Research

Bela Anand-Apte, MBBS, PhD

Research Interests:

eye; angiogenesis; diabetic retinopathy; blood retinal barrier; retinal vascular leakage; macular edema; macular degeneration; sorsbys fundus dystrophy; tissue inhibitor of metalloproteinases

Brian D. Perkins, PhD

Research Interests:

Zebrafish; retina; photoreceptor; cilia; cep290; microRNA

Alex Yuan, MD, PhD

Research Interests:

Regenerative medicine and stem cell biology; retinal injury response; cell-based therapy; gene and drug delivery

Translational Hematology & Oncology

Mohamad Abazeed, MD

Research Interests:

translational hematology and oncology research

Li Lily Wang, PhD

Research Interests:

The current research interest of our laboratory is to define the mechanisms by which immune checkpoint proteins regulate anti-tumor immune responses and to develop rational therapeutics for cancer immunotherapy.