The Ahern lab focuses on understanding the homeostasis between the intestinal immune system and gut microbiota, and how imbalances contribute to the development and exacerbation of inflammatory bowel disease.
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The Anand-Apte lab studies the basic molecular mechanisms of ocular neovascularization and the pathways that regulate breakdown of the blood-retinal barrier in diabetic retinopathy.
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The Apte lab studies extracellular matrix and proteases and their effects on various diseases, including Marfan syndrome and the acromelic dysplasias.
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The Aronia lab researches the role of several components of the extracellular matrix in the development and pathogenesis of asthma.
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The Baldwin lab studies the mechanisms through which antibodies alter lymphocyte responses in endothelial cells, platelets and leukocytes in the context of vascular pathology.
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The Bergmann lab explores how the immune system controls viral infections of the central nervous system.
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The Bonilha lab studies aging in the retina and retinal pigment epithelium (RPE) and how age-related macular degeneration (AMD) pathology affects RPE cellular function.
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The Brown lab studies the interrelationship between diet, lipid metabolism and the development of chronic disease.
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The Chakraborty lab studies chromatin biology in the context of dysregulated activity of oxygen-dependent enzymes (or dioxygenase), such as the JumonjiC-family histone demethylases.
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The Chan lab is interested in precision immuno-oncology and the genomic basis of tumor development and treatment response.
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The Cheng lab develops and utilizes innovative network medicine methodologies and systems biology technologies to predict drug targets and identify mechanisms of human diseases.
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The Claesen lab aims to functionally characterize molecular mechanisms that control bacterial interspecies and microbe-host interactions in the human microbiome.
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The Corey lab focuses on pediatric hematology and diseases including Shwachman-Diamond syndrome (SDS).
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The Damaser lab studies regenerative medicine, tissue engineering and device development for pelvic floor dysfunction, including urinary and fecal incontinence and pelvic organ prolapse.
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The Davalos lab studies the role that neuroimmune mechanisms play in brain function under physiological conditions and during neurological disease.
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The de la Motte lab focuses on innate mechanisms of intestinal protection that lead to disease when dysregulated.
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The DeSilva lab studies myelination, focusing on blocking immune cell infiltration into the central nervous system (CNS), protecting the CNS during infiltration and promoting regeneration of myelin.
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The Driscoll lab researches how selenoproteins are synthesized and how this pathway is affected in selenium insufficiency.
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The Eng lab identifies and characterizes genes that cause susceptibility to inherited cancer syndromes, ellucidating their role in sporadic carcinogenesis and clinical utility in diagnosis and treatment.
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The Erzurum lab studies the mechanisms that initiate and perpetuate lung inflammation and remodeling and ultimately lead to lung diseases such as asthma and pulmonary vascular disease.
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The Fairchild lab studies the role of innate immune mechanisms and CD8+ T cells in contact hypersensitivity, as well as the role of inflammatory/signaling proteins in allograft inflammation and rejection.
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The Graham lab investigates bypass graft and arterial healing after balloon angioplasty and stenting.
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The Hazen lab studies the mechanisms through which inflammation contributes to diseases like atherosclerosis and asthma, and the link between gut microbes and cardiovascular disease.
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The Hu lab works to develop novel statistical and machine learning methods for personalized medicine.
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The Huang lab seeks to define how elements of the epithelia and the surrounding microenvironment interact to promote progression to cancer, particularly colorectal cancer, or conversely, to mitigate the progression.
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The Hwang lab develops novel machine learning, artificial intelligence and computational/bioinformatics algorithms and tools to gain new insights into genetic/phenotypic variants of human disease
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The Jorgensen lab focuses on the effects of sex hormones on the immune system during initiation/progression of lupus-like disease and the specific role played by type I interferons.
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The Jung lab investigates virus-induced cancers, including Kaposi’s sarcoma, coronaviruses and other emerging pathogens.
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The Lal lab focuses on discovering genes related to epilepsy syndromes, developing novel methods for interpreting missense variants and characterizing patient disease trajectories.
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The Lathia lab’s main interest is how cancer stem cells from malignant brain tumors interact with their surrounding microenvironment, which provides signals to preserve the malignancy of these cells and drive cancer progression, paying close attention to these mechanisms in the context of glioblastoma.
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The Labhasetwar lab studies nanotechnology for the detection and treatment of various diseases.
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The Li lab studies musculoskeletal imaging techniques for a range of orthopaedic and rheumatologic disorders.
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The Li lab investigates the signaling mechanisms in innate and adaptive immunity.
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The Lin lab is interested in studying complement system activation and regulation in innate immunity.
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The Louveau lab investigates the role of the meninges in normal and pathological brain function to identify therapeutics for neurological disorders that target the meningeal compartment.
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The Longworth lab investigates how changes to DNA organization within the nucleus of a cell impact development and disease.
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The Mian lab explores the genetic and epigenetic mechanisms underlying lethal cancers of the genitourinary tract with the goal of translating discovery in to novel therapies.
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The Mata lab studies genes that impact neurological disorders, including Parkinson’s disease, with a particular focus on underrepresented populations, especially Latinos.
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The McDonald lab investigates immune response control and how alterations in these responses contribute to the development of Crohn’s disease.
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The Nagy lab studies how chronic alcohol consumption contributes to diseases such as liver disease and diabetes.
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The O’Connor lab researches cytomegalovirus infection, pathogenesis and disease.
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The Padgett lab focuses on mechanisms of post-transcriptional RNA processing, particularly pre-mRNA splicing.
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The Perkins lab investigates photoreceptor degeneration and regeneration.
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The Plow lab studies the potential of rehabilitation, movement re-learning and noninvasive brain stimulation to prevent or promote recovery following brain injury, including stoke.
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The Rao lab is interested in understanding how neurons and vasculature pattern themselves and interact with each other during development as well as in disease.
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The Reizes lab studies pathways related to the development and pathogenesis of women’s cancers, including triple negative breast cancer and gynecologic cancers, to develop novel targeted therapies.
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The Rubin lab seeks to understand the pathogenesis of bone and soft tissue cancers, collectively known as sarcomas.
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The Saunthararjah lab works to develop therapies that selectively destroy malignant cells while sparing normal stem cells, searching for alternatives to traditional therapies like chemo- and radiation therapy.
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The Scott lab uses mathematical and experimental models to help increase the efficacy of targeted therapies and radiation for cancers.
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The Schumacher-Bass lab studies the mechanisms that underlie the transition from adaptive to adverse vascular remodeling, including changes in cardiac structure, function, metabolism, fibrosis and arrhythmogenesis.
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The Sharifi lab studies fundamental metabolic processes that govern prostate cancer progression.
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The Smith lab applies principles of cell/molecular biology, biochemistry and genetics/genomics to study cardiovascular diseases, including atherosclerosis, atrial fibrillation and lipid metabolism
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The Stappenbeck lab researches host and environmental factors that impact inflammation and wound repair, which influence the pathogenesis of diseases including inflammatory bowel disease.
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The Stark lab studies the complex interactions of cells in innate immunity and cancer
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The Stenina Adognravi lab studies the vascular complications of diabetes.
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The Ting lab examines the mechanisms of epigenetic gene silencing and the functional relevance of DNA methylation in cancer.
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The Trapp lab explores the cause of permanent neurological disability in multiple sclerosis (MS) and focuses on pathological and molecular changes in postmortem MS brains.
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The Valujskikh lab investigates the functions of graft-reactive memory CD4 T cells in organ transplant, with the ultimate goal to develop combinatorial therapies for sensitized transplant recipients.
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The Wang lab seeks to define the mechanisms by which immune checkpoint proteins regulate anti-tumor immune responses and to develop novel therapeutics for cancer immunotherapy
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The Wessely lab studies the molecular mechanisms governing kidney formation and maintenance and how these processes are perturbed during kidney diseases
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The Williams lab investigates the interplay between the immune and central nervous systems during multiple sclerosis (MS) in order to uncover novel therapeutic options for MS patients
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The Yuan lab’s primary goal is to characterize the retina’s wound healing and regenerative responses in order to develop novel methods for retinal repair.
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